HYPERTROPHIC CARDIOMYOPATHY

This study tests a new gene therapy, TN-201, in 30 adults with a type of heart muscle disease caused by a specific gene mutation (MYBPC3). The goal is to see if it is safe and can improve heart function and symptoms. Participants receive a single dose and are followed for side ef…

This study checks the long-term safety of a drug called HRS-1893 in 300 people with hypertrophic cardiomyopathy, a condition where the heart muscle thickens. Participants must have taken HRS-1893 in a past study. Researchers will monitor side effects and heart function, like ejec…

This study is testing how well the drug mavacamten works for Chinese adults with a type of heart disease called obstructive hypertrophic cardiomyopathy. About 500 people will take the drug as part of their normal care, and doctors will measure changes in heart function and sympto…

This study looks at whether moderate exercise training can improve symptoms and heart function in people with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle is thickened. About 70 adults aged 18 to 80 with HCM will be randomly assigned to either a moderate …

This study is creating a large database to collect information about people with rare diseases like amyloidosis, sarcoidosis, and many others. Researchers will track patients' health, treatments, and outcomes over time. The goal is to better understand these conditions and improv…

This study monitors the health of women who took the heart medication mavacamten during pregnancy or while breastfeeding, along with their babies. Researchers will track pregnancy complications, birth outcomes, and infant development through the first year of life. The goal is to…

This study is a registry that will collect information from about 1000 people with hypertrophic cardiomyopathy (a condition where the heart muscle is thickened) across multiple clinics in Austria. Researchers will gather data from medical records, tests, and genetic testing to be…