HIV-1-INFECTION

This study tests whether a combination of three existing drugs (topiramate, lenalidomide, and pyrimethamine) can wake up dormant HIV hiding in the body and help the immune system clear it. 30 adults with well-controlled HIV will receive the drugs in two phases to measure safety a…

This early-stage study tests whether two lab-made antibodies can safely help people with HIV keep the virus under control after stopping their daily antiretroviral therapy. The study involves 40 adults who started HIV treatment very early after infection. Participants will receiv…

This early-stage study tests the safety of a single dose of a new experimental drug, IAP086, in 30 people with HIV whose virus is already well-controlled by their regular antiretroviral therapy (ART). Participants will receive one infusion of IAP086 and be closely monitored for s…

This study looks at whether people with HIV who have stopped taking their medication for at least 12 weeks can safely restart the same day they return to care. About 200 adults will take the once-daily pill B/F/TAF. Researchers will check if the virus stays under control and if p…

This study tests whether a common chemotherapy drug, paclitaxel, works as well as a more expensive one, pegylated liposomal doxorubicin, for treating Kaposi sarcoma in people with HIV. About 130 participants in sub-Saharan Africa will receive one of the two drugs every three week…

This study will follow 200 people with HIV who are already virally suppressed to see how many stay on a long-acting injectable treatment (cabotegravir and rilpivirine) given every 2 months instead of daily pills. The goal is to measure how many continue the shots without stopping…

This study tests a three-drug pill (doravirine, lamivudine, tenofovir) for people newly diagnosed with HIV who have never taken HIV medications. The goal is to see if starting this treatment quickly can suppress the virus to undetectable levels by 48 weeks. About 100 adults will …

This study aims to find better ways to help people living with HIV who also have high blood pressure take their blood pressure medications regularly. Researchers will interview patients and providers to identify barriers, then test a nurse-supported program. The goal is to improv…

This study looks at how short-term methamphetamine use affects the hidden HIV virus in people who are already on effective HIV treatment. About 20 adults with well-controlled HIV will take oral methamphetamine under medical supervision. Researchers will measure changes in virus a…