HEALTHY SUBJECTS

This early-stage study tests a new drug called TLC-6740 in healthy volunteers and people with obesity, with or without type 2 diabetes. The goal is to check the drug's safety, how the body processes it, and its potential to help with weight and blood sugar control. About 564 part…

This study is testing a new imaging agent called [18F]FT8 for PET/CT scans to see if it can safely and clearly show amyloid deposits in people with amyloidosis, a condition where abnormal proteins build up in organs. Researchers will compare the new scan with standard tests like …

This study tests a new, painless way to check for heart valve diseases using a finger scanner. About 15 adults with aortic stenosis, aortic regurgitation, or no heart disease will place a finger in a device that uses light and sound to measure blood flow. Researchers want to see …

This early-phase study tests the safety and radiation exposure of a new imaging agent called Radiocaine™ in 6 healthy adults. The tracer is designed to bind to sodium channels in the body, which could help doctors see nerve activity in future scans. The goal is to gather safety d…

This early-stage study tests whether a vaginal film containing an anti-sperm antibody is safe for healthy women aged 18 to 45. Participants will use the film either once or daily for two weeks. The goal is to check for side effects and see how the antibody spreads in the body.

This early-stage study tests a new injection called HEC-007 to see if it is safe and how the body processes it. It involves 126 healthy adults and overweight or obese volunteers. Researchers will monitor side effects and measure changes in weight, waist size, and blood sugar leve…

This early-stage study tests a single dose of a new drug called GTX-B001 in healthy volunteers and people with chronic inducible urticaria — a condition where cold or scratching causes painful hives. The main goal is to check safety and side effects. About 72 people will take par…

This study tests a new drug called BGB-45035 for the first time in humans. It will check safety and how the body processes the drug in healthy volunteers, then test it in people with autoimmune skin diseases like eczema and prurigo nodularis. The goal is to see if the drug is saf…

This early-stage study tests a new drug called SOB100 in 15 healthy adults. SOB100 is a tiny particle (exosome) designed to target a protein called HLA-G. The main goal is to check if it is safe and how the body processes it. No treatment benefit is expected for participants.

This study aims to improve MRI scans by testing new ways to take images. The goal is to get clearer pictures while making the exam more comfortable for patients. Researchers will compare the new methods to standard ones in 720 healthy adults and people already scheduled for an MR…

This study looks at how the immune system in the nose responds to respiratory viruses like COVID-19 in people with weakened immune systems compared to healthy volunteers. Researchers will collect samples from 40 adults aged 18 to 90 to measure immune cell activity. The goal is to…

This study tests whether offering a small $25 financial incentive helps recruit a more diverse group of older adults into the Alzheimer's Prevention Trial (APT) Webstudy, a registry that connects people with future clinical trials. Researchers will compare the $25 offer to a non-…

This study looks at bladder and bowel problems in children aged 5 to 12 with intellectual disabilities and compares them to typically developing children. Researchers want to understand how these issues affect the child's participation in daily activities and the family's quality…

This study tests a new way to use a standard PET scan tracer (FDG) to measure both blood flow and sugar use in the heart at the same time. Researchers will compare these measurements to those from a separate tracer that only measures blood flow. The goal is to simplify heart imag…

This study looks at how problems with the immune system can lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from 700 people, including those with genetic immune defects and healthy volunteers. The goal is to understand t…

This study aims to see if newer CT scanning methods that use less radiation can create images just as clear as traditional CT scans. Researchers will enroll 215 healthy adults who already need a CT scan of their chest, abdomen, and pelvis. Participants will have one extra low-rad…

This early-stage study tests a new drug called CM559 in healthy adult men to see if it is safe and how the body handles it. About 40 participants will receive a single dose of CM559 or a placebo. The study focuses on side effects and how the drug moves through the body, not on tr…

This study tests a new, non-invasive brain scan called fNIRS to see if it can predict recovery in unconscious ICU patients with severe stroke or brain injury. Researchers will compare fNIRS results with standard tests like evoked potentials and EEG. The goal is to find a simpler …

This study looks at whether red blood cells treated with the INTERCEPT system survive just as well as untreated cells after being stored for 35 days. About 70 healthy adults will receive both treated and untreated labeled blood cells, and researchers will measure how many are sti…

This early-stage study is looking at how a new drug called HDM1002 interacts with five common medications (metformin, empagliflozin, midazolam, valsartan, and warfarin) in overweight or obese adults. The goal is to see if taking them together changes drug levels in the body and t…

This early-stage study tests the safety of a new drug, BEAM-103, in 30 healthy adults aged 18 to 55. Participants receive a single infusion of the drug or a placebo and are monitored for up to 4 months. The goal is to gather safety and dosing information, not to treat any disease…

This study looks at how muscle temperature changes the look of ultrasound images. Researchers will heat and then cool the thigh muscles of 30 healthy adults, taking ultrasound pictures and temperature readings throughout. The goal is to understand this effect so doctors can use u…

This study looks at people who carry gene changes linked to Leber hereditary optic neuropathy (LHON) but still have normal vision. Researchers want to see if certain chemicals in the blood and tears can show early nerve damage in the eye, before vision gets worse. About 90 partic…