HEALTHY CONTROLS

This study tests a new, ultra-low dose PET scan that uses 10 to 100 times less radiation than standard scans to find neuroendocrine tumors. About 200 healthy volunteers and people with these tumors will get a radioactive tracer and be scanned for up to 3 hours. The goal is to see…

This early study tests a new, personalized brain stimulation method (tACS) for depression during pregnancy. Ten women (5 with depression and 5 healthy) will receive the treatment to see if it is safe, tolerable, and practical. The goal is to gather initial data to guide larger fu…

This study tests whether a technique called Graded Motor Imagery (GMI) — a series of mental exercises that involve thinking about and visualizing ankle movements — can improve pain, stiffness, strength, and balance in people with chronic ankle instability. About 48 adults (half w…

This study looks at whether a single session of whole-body heat therapy, with or without a cold water plunge, can reduce symptoms of depression. Researchers will enroll 162 adults aged 18-65 who currently have depressive symptoms. Participants will be randomly assigned to receive…

This study aims to understand why people with Lewy body dementia experience sudden changes in attention and thinking, known as cognitive fluctuations. Researchers will use skin biopsies, brain scans, and EEG monitoring in 120 participants, including healthy volunteers. The goal i…

This study uses PET scans with a special tracer to measure the density of synapses (connections between brain cells) in people with cocaine use disorder compared to healthy volunteers. Researchers aim to see if cocaine changes brain connections, especially in areas linked to deci…

This study uses low-intensity focused ultrasound (LIFU) to temporarily and safely change activity in deep brain areas. Researchers will scan the brains of 66 healthy adults to see how different doses of ultrasound alter communication between brain regions. The goal is to understa…

This study tests a new brain stimulation technique called transcranial interference stimulation (tIS) in 10 healthy adults. The goal is to see if it is safe and can temporarily change how the brain processes emotions in faces. If it works, this method might one day help treat con…

This early-stage trial at the Cleveland Clinic is studying how a specific type of hyaluronic acid (HA35) affects muscle protein in 24 healthy adults. Participants take either HA35 or a placebo capsule for three days, then undergo tests including muscle biopsies and a gut permeabi…

This study uses PET and MRI scans to look at serotonin pathways in the brainstem of adults with Dravet syndrome, a severe form of epilepsy. Researchers want to see if these pathways are different in Dravet patients compared to those with other drug-resistant epilepsy and healthy …

This observational study tests whether DANU Smart Socks can accurately measure walking and balance in people with Parkinson's disease. Researchers will compare data from 60 participants (30 with Parkinson's and 30 healthy older adults) during a single lab visit. The goal is to se…

This study creates a repository of microbiome samples (like stool, saliva, and skin swabs) from up to 600 people of all ages, including healthy volunteers and those with various conditions. Researchers will use these samples to study how the microbiome affects health and disease,…

This study uses brain scans (fMRI) to understand why people with bipolar disorder experience unstable moods compared to healthy individuals. Researchers will ask 72 participants to recall personal memories and practice boosting positive feelings while their brain activity is reco…

This early-phase study tests a new radioactive tracer called [11C]SY08 to see if it can detect clumps of alpha-synuclein protein in the brain using PET scans. Researchers will scan 40 volunteers, including healthy people and those with Parkinson's disease, multiple system atrophy…

This study explores whether very small, barely noticeable movements can help retrain the brain's balance system in people with inner ear problems. Researchers will test balance and motion sensitivity in 48 adults with certain balance disorders and healthy volunteers. The goal is …

This study looks at how two rare diseases that cause blood vessel inflammation—Takayasu arteritis and Behçet's disease—affect physical strength, breathing, daily function, and emotional well-being. Researchers will compare 30 participants (patients and healthy volunteers) using s…

This study looks at how the antipsychotic medication haloperidol may block insulin action in the brain, which could explain why these drugs often cause weight gain and diabetes. Researchers will give healthy volunteers either haloperidol or a placebo and use brain scans to measur…