HEADACHE
Clinical trials for HEADACHE explained in plain language.
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Eye ultrasound may spot spinal headache risk
Diagnosis CompletedThis study tested whether measuring the optic nerve sheath with ultrasound can predict postdural puncture headache (PDPH) after spinal anesthesia. 176 adults having knee replacement surgery were scanned before and after the procedure. The goal was to see if changes in nerve sheat…
Matched conditions: HEADACHE
Sponsor: Ankara City Hospital Bilkent • Aim: Diagnosis
Last updated Jun 23, 2026 11:58 UTC
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Blood test may spot dangerous headaches in the ER
Diagnosis CompletedThis study looked at 81 people with bad headaches in the emergency room. Doctors measured a protein called S100B in their blood to see if it could tell the difference between a harmless headache and one caused by a more serious problem. The goal was to find a quick, simple way to…
Matched conditions: HEADACHE
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Diagnosis
Last updated Jun 15, 2026 19:06 UTC
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Acupuncture may ease headaches during IVF, small study suggests
Symptom relief CompletedThis pilot study tested whether acupuncture can help headaches in women going through IVF egg stimulation. 37 women received a 30-minute acupuncture session. Researchers measured headache intensity, stress, and emotional distress before and after treatment. The study is small and…
Matched conditions: HEADACHE
Phase: NA • Sponsor: Yo San University of Traditional Chinese Medicine • Aim: Symptom relief
Last updated Jun 23, 2026 20:31 UTC
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New nerve procedure shows promise for stubborn headaches
Symptom relief CompletedThis study tested a procedure called pulsed radiofrequency treatment on the greater occipital nerve at the C2 level in 25 people with cervicogenic headache who had not responded to other treatments. The goal was to see if it could reduce headache severity and frequency. The treat…
Matched conditions: HEADACHE
Phase: NA • Sponsor: Ankara City Hospital Bilkent • Aim: Symptom relief
Last updated Jun 23, 2026 12:00 UTC
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Could a blood pressure drug ease Veterans' Post-Concussion headaches?
Symptom relief CompletedThis study tested whether prazosin, a drug used for high blood pressure and PTSD nightmares, can reduce headaches in veterans and service members who had a mild traumatic brain injury. 89 participants received either prazosin or a placebo for 12 weeks. Researchers tracked headach…
Matched conditions: HEADACHE
Phase: PHASE1, PHASE2 • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Jun 23, 2026 11:58 UTC
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Spinal tap may offer headache relief for brain bleed survivors
Symptom relief CompletedThis study tested whether draining some fluid from the spine (a lumbar puncture) can help relieve severe headaches that often follow a brain aneurysm rupture. The trial involved 74 patients with mild to moderate brain bleeds. Half received a real lumbar puncture, and half receive…
Matched conditions: HEADACHE
Phase: NA • Sponsor: University Hospital, Toulouse • Aim: Symptom relief
Last updated Jun 23, 2026 11:58 UTC
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Hands-On therapy and Brain-Body exercises show promise for Jaw-Related headaches
Symptom relief CompletedThis study looked at whether manual therapy (hands-on treatment) plus a cognitive exercise program called BETY can reduce headache pain and improve quality of life in people with temporomandibular disorder (TMD)-related headaches. Sixty adults aged 18 to 60 with TMD headaches too…
Matched conditions: HEADACHE
Phase: NA • Sponsor: Hasan Kalyoncu University • Aim: Symptom relief
Last updated Jun 22, 2026 12:09 UTC
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Could a gentle zap to the neck ease long COVID fatigue?
Symptom relief CompletedThis pilot study tested whether a non-invasive vagus nerve stimulator can help people with post-COVID syndrome who suffer from fatigue and headaches. Eighteen participants used the device, and researchers measured changes in their functional status and fatigue levels. The goal is…
Matched conditions: HEADACHE
Phase: NA • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Jun 22, 2026 11:59 UTC
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Nasal nerve block offers quick headache relief after spinal needle accident
Symptom relief CompletedThis study tested whether a nasal nerve block (sphenopalatine ganglion block) could ease severe headaches that sometimes happen after accidental spinal needle puncture during epidural procedures. 26 adults were randomly assigned to receive either the nerve block or standard care …
Matched conditions: HEADACHE
Phase: NA • Sponsor: ISSSTE Hospital Regional "Gral. Ignacio Zaragoza" • Aim: Symptom relief
Last updated Jun 16, 2026 12:49 UTC
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ER migraine study: does a simple IV drip ease Kids' pain?
Symptom relief CompletedThis study looked at whether giving children with migraine an IV of salt water (a common fluid) in the emergency room can help reduce their headache pain. 46 children took part. The goal was to see if the fluid alone, without any other medicine, could make them feel better.
Matched conditions: HEADACHE
Phase: PHASE1, PHASE2 • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 16, 2026 12:48 UTC
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AI-Written summaries boost understanding of brain scans, study finds
Knowledge-focused CompletedThis study tested whether adding an AI-generated summary to brain MRI reports helps people understand the results. Over 2700 adults read six fictional reports and answered questions about what they found. The goal was to see if the simple summary improved understanding compared t…
Matched conditions: HEADACHE
Phase: NA • Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 23, 2026 20:41 UTC
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Walking may boost brain health in overweight adults, small study hints
Knowledge-focused CompletedThis study looked at whether a 12-week walking program could change brain structure in 22 overweight adults who also had headaches. Participants either followed a diet plus walking or diet alone. Researchers measured brain gray and white matter volumes with MRI scans before and a…
Matched conditions: HEADACHE
Phase: NA • Sponsor: Amasya University • Aim: Knowledge-focused
Last updated Jun 23, 2026 12:09 UTC
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Heart drug tested as migraine shield in small trial
Knowledge-focused CompletedThis study looked at whether ivabradine, a medicine used for heart conditions, could stop migraines triggered by another drug called levcromakalim. 37 adults with migraine without aura took part. The goal was to see if ivabradine could reduce the number of migraines caused by the…
Matched conditions: HEADACHE
Phase: NA • Sponsor: Danish Headache Center • Aim: Knowledge-focused
Last updated Jun 17, 2026 12:10 UTC