GRAVES DISEASE

This study tests two doses of rilzabrutinib in 30 adults with Graves' disease, an autoimmune condition causing an overactive thyroid. The goal is to see if the drug can safely lower thyroid hormone levels and improve symptoms, including eye problems. Participants take the drug fo…

This early-stage study tests a new drug called MER511 in 100 adults with Graves' disease, a condition where the immune system attacks the thyroid. The goal is to see if the drug is safe and how the body handles it. Participants will receive the drug either through a vein or under…

This early-stage study tests whether BHV-1300 is safe for people with Graves' disease, an autoimmune condition that causes an overactive thyroid. About 15 adults will receive the drug and be monitored for side effects and changes in disease markers. The goal is to see if the drug…

This study tests an experimental drug called IMVT-1402 in 210 adults with Graves' disease whose thyroid is still overactive despite standard medication. The goal is to see if the drug can help patients achieve normal thyroid levels and stop taking their current thyroid medication…

This study tests a computer model called OptiThyDose that helps doctors calculate the right dose of thyroid medication for children with congenital hypothyroidism or Graves' disease. About 150 children will be randomly assigned to get dosing guided by the model or by standard car…

This study tests whether adding high-dose vitamin D to standard medication can help children aged 9–17 with newly diagnosed Graves' disease. About 30 participants will receive either vitamin D plus methimazole or methimazole alone. The main goal is to see if a larger trial is pos…

This study tests a new treatment called HN2301 for people with Graves' disease that hasn't improved with standard therapy. HN2301 uses a special injection to turn the body's own immune cells into cells that attack the overactive thyroid. The goal is to safely bring thyroid levels…

This early-stage study tests a new treatment called RD06-05, made from donor immune cells engineered to target and calm the faulty immune response in Graves' disease. It aims to see if a single infusion can safely restore normal thyroid function without needing lifelong medicatio…

This study tests an experimental drug called IMVT-1402 for adults with Graves' disease whose thyroid is still overactive despite taking standard antithyroid medications. About 240 participants will receive either the drug or a placebo to see if it can bring thyroid hormone levels…

This early-stage study tests a single injection of a new drug called GenSci098 in 24 adults with Graves' disease, a condition where the thyroid is overactive. The main goal is to see if the drug is safe and what side effects it might cause. Participants must have stopped other th…

This study tests whether a person-centred care (PCC) program, delivered by phone and online, can reduce mental fatigue and sick leave in 220 adults with Graves' disease. Participants will either receive usual care or usual care plus the PCC program. The goal is to see if this app…

This study tests the safety of a new, less invasive procedure called thyroid artery embolization (TAE) for people with large, non-cancerous thyroid lumps or an overactive thyroid. Instead of surgery or other treatments, doctors block the blood supply to the thyroid using tiny par…

This study tests whether a special course on managing mental fatigue can improve brain fog, exhaustion, and quality of life in people with Graves' disease. About 96 adults with persistent mental fatigue will either take the course plus standard care or receive standard care alone…

This study examines how inflammation and thyroid antibodies relate to changes in the retina and optic nerve in people with Graves disease. Researchers will review medical records of 100 adults, comparing those with Graves disease (with or without eye involvement) to healthy contr…

This study looks at how changing thyroid hormone levels impact the way the body uses sugar and fat. Researchers will measure insulin sensitivity and energy use in 60 people with Graves' disease or thyroid cancer before and after their hormone levels are adjusted. The goal is to b…

This study aims to understand why some people with Graves' disease continue to experience mental fatigue even after their thyroid levels return to normal. Researchers will compare blood and spinal fluid samples from 180 participants—60 with mental fatigue, 60 without, and 60 heal…

This study is testing a special collar worn around the neck that measures how the body processes radioactive iodine used to treat thyroid cancer and Graves disease. The goal is to see if this device can give doctors better information to personalize the dose for each patient, pot…