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New drug aims to tame overactive thyroid without lifelong pills

NCT ID NCT07018323

Disease control Sponsor: Immunovant Sciences GmbH Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 26, 2026 · Updated 8 times

Summary

This trial tests a new drug called IMVT-1402 for adults with Graves' disease, a condition where the thyroid is overactive. The study will include 210 participants who still have high thyroid levels despite taking standard medications. Participants will receive either one of two doses of IMVT-1402 or a placebo for 26 weeks. The main goal is to see if the drug can help patients achieve normal thyroid function and stop taking other thyroid medications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
IMVT-1402
What this could lead to
If successful, this could offer a new treatment option for Graves' disease that helps patients achieve normal thyroid function without needing ongoing antithyroid drugs.
What could go wrong
This is an early Phase 2b trial with only 210 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 210 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants with the ability to understand the requirements of the trial, provide written informed consent, and comply with the trial protocol procedures. * Male or female participants aged ≥ 18 years. * Participants with diagnosis of GD who are hyperthyroid despite ATD treatment. * Other, more specific inclusion criteria are defined in the protocol. Exclusion Criteria: * Have previously been successfully treated with radioactive iodine (RAI) therapy or have undergone total thyroidectomy. * Have an autoimmune disease other than GD requiring treatment that, in the Investigator's judgment, puts the participant at undue risk. * Have moderate-to-severe active thyroid eye disease (TED) and are expected to require immediate surgical intervention and/or are planning corrective surgery/irradiation or medical therapy for TED during study participation. * Additional exclusion criteria are defined in the protocol.

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

Graves disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Graves disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    163 sites in 18 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Site Nnumber - 3003

    RECRUITING

    Wroclaw, 50-367, Poland

  • Site Number - 1000

    RECRUITING

    Miami, Florida, 33143, United States

  • Site Number - 1001

    RECRUITING

    Morehead City, North Carolina, 27577, United States

  • Site Number - 1002

    RECRUITING

    El Paso, Texas, 79935, United States

  • Site Number - 1003

    RECRUITING

    Fort Worth, Texas, 76132, United States

  • Site Number - 1004

    RECRUITING

    Kansas City, Missouri, 64110, United States

  • Site Number - 1007

    RECRUITING

    Oklahoma City, Oklahoma, 73134, United States

  • Site Number - 1008

    RECRUITING

    Hialeah, Florida, 33016, United States

  • Site Number - 1009

    RECRUITING

    New York, New York, 10022, United States

  • Site Number - 1010

    RECRUITING

    Chapel Hill, North Carolina, 27514, United States

  • Site Number - 1011

    RECRUITING

    San Antonio, Texas, 78231, United States

  • Site Number - 1012

    RECRUITING

    Reno, Nevada, 89511, United States

  • Site Number - 1013

    RECRUITING

    Aurora, Colorado, 80045, United States

  • Site Number - 1015

    RECRUITING

    Tucson, Arizona, 85710, United States

  • Site Number - 1016

    RECRUITING

    Norfolk, Virginia, 23510, United States

  • Site Number - 1017

    RECRUITING

    Memphis, Tennessee, 38119, United States

  • Site Number - 1018

    RECRUITING

    Williamsville, New York, 14221, United States

  • Site Number - 1019

    RECRUITING

    St Louis, Missouri, 63110, United States

  • Site Number - 1020

    RECRUITING

    Columbus, Georgia, 31904, United States

  • Site Number - 1021

    RECRUITING

    Irving, Texas, 75039, United States

  • Site Number - 1022

    RECRUITING

    Topeka, Kansas, 66606, United States

  • Site Number - 1024

    RECRUITING

    Doral, Florida, 33166, United States

  • Site Number - 1025

    RECRUITING

    McKinney, Texas, 75069, United States

  • Site Number - 1026

    RECRUITING

    Hickory, North Carolina, 28601, United States

  • Site Number - 1027

    RECRUITING

    New Hyde Park, New York, 11434, United States

  • Site Number - 1028

    RECRUITING

    Houston, Texas, 77054, United States

  • Site Number - 1029

    RECRUITING

    Dallas, Texas, 75224, United States

  • Site Number - 1030

    RECRUITING

    Louisville, Kentucky, 40202, United States

  • Site Number - 1031

    RECRUITING

    Houston, Texas, 77030, United States

  • Site Number - 1032

    RECRUITING

    Long Island City, New York, 11106, United States

  • Site Number - 1033

    RECRUITING

    Jefferson City, Missouri, 65109, United States

  • Site Number - 1034

    RECRUITING

    Raleigh, North Carolina, 27612, United States

  • Site Number - 2003

    RECRUITING

    Rotterdam, South Holland, 3045 PM, Netherlands

  • Site Number - 2200

    RECRUITING

    Rotterdam, South Holland, 3079 DZ, Netherlands

  • Site Number - 2201

    RECRUITING

    Rotterdam, South Holland, 3083 AN, Netherlands

  • Site Number - 2202

    RECRUITING

    Zwijndrecht, South Holland, 3318 AT, Netherlands

  • Site Number - 3000

    RECRUITING

    Lublin, 20-607, Poland

  • Site Number - 3001

    RECRUITING

    Szczecin, West Pomeranian Voivodeship, 71-252, Poland

  • Site Number - 3002

    RECRUITING

    Bydgoszcz, 85-605, Poland

  • Site Number - 3004

    RECRUITING

    Bialystok, Podlaskie Voivodeship, 15-276, Poland

  • Site Number - 3005

    RECRUITING

    Olsztyn, 10-117, Poland

  • Site Number - 3006

    RECRUITING

    Poznan, 60-693, Poland

  • Site Number - 3007

    RECRUITING

    Kielce, 25-734, Poland

  • Site Number - 3008

    RECRUITING

    Warsaw, 02-482, Poland

  • Site Number - 3009

    RECRUITING

    Opole, 45-301, Poland

  • Site Number - 3010

    RECRUITING

    Chorzów, 41-516, Poland

  • Site Number - 3011

    RECRUITING

    Warsaw, 02-507, Poland

  • Site Number - 3200

    RECRUITING

    Prague, 181 00, Czechia

  • Site Number - 3201

    RECRUITING

    Prague, 149 00, Czechia

  • Site Number - 3202

    RECRUITING

    Prague, 190 14, Czechia

  • Site Number - 3203

    RECRUITING

    Náchod, 547 01, Czechia

  • Site Number - 3300

    RECRUITING

    Wellington, 6242, New Zealand

  • Site Number - 3301

    RECRUITING

    Auckland, 2025, New Zealand

  • Site Number - 3900

    RECRUITING

    Athens, 115 27, Greece

  • Site Number - 3901

    RECRUITING

    Athens, 115 28, Greece

  • Site Number - 3902

    RECRUITING

    Athens, 106 76, Greece

  • Site Number - 3903

    RECRUITING

    Thessaloniki, 546 42, Greece

  • Site Number - 4001

    RECRUITING

    Kamogawa, Chiba, 296-0041, Japan

  • Site Number - 4002

    RECRUITING

    Nagasaki, 852-8501, Japan

  • Site Number - 4003

    RECRUITING

    Nankoku, Kochi, 791-0295, Japan

  • Site Number - 4004

    RECRUITING

    Kurume, Fukuoka, 830-0011, Japan

  • Site Number - 4005

    RECRUITING

    Minokamo, Gifu, 505-8510, Japan

  • Site Number - 4006

    RECRUITING

    Kyoto, 612-8555, Japan

  • Site Number - 4007

    RECRUITING

    Kumamoto, 860-8556, Japan

  • Site Number - 4008

    RECRUITING

    Maebashi, Gunma, 371-8512, Japan

  • Site Number - 4009

    RECRUITING

    Yokohama, Kanagawa, 230-8765, Japan

  • Site Number - 4010

    RECRUITING

    Nagoya, Aichi-ken, 467-8602, Japan

  • Site Number - 4011

    RECRUITING

    Kitakyushu, Fukuoka, 807-8555, Japan

  • Site Number - 4012

    RECRUITING

    Shibuya City, Tokyo, 150-8308, Japan

  • Site Number - 4200

    RECRUITING

    Petah Tikva, 4941492, Israel

  • Site Number - 4201

    RECRUITING

    Jerusalem, 9103102, Israel

  • Site Number - 4202

    RECRUITING

    Ramat Gan, Central District, 5265601, Israel

  • Site Number - 4203

    RECRUITING

    Haifa, Haifa District, 3109601, Israel

  • Site Number - 4204

    RECRUITING

    Jerusalem, 9112001, Israel

  • Site Number - 4205

    RECRUITING

    Haifa, Haifa District, 3104802, Israel

  • Site Number - 4206

    RECRUITING

    Tzfat, Northern District, 1311001, Israel

  • Site Number - 4207

    RECRUITING

    Tel Aviv, 6423906, Israel

  • Site Number - 4208

    RECRUITING

    Rehovot, 7661041, Israel

  • Site Number - 4209

    RECRUITING

    Nahariya, Northern District, 2210001, Israel

  • Site Number - 4210

    RECRUITING

    Kfar Saba, 4428164, Israel

  • Site Number - 4211

    RECRUITING

    Beersheba, Southern District, 8410101, Israel

  • Site Number - 4500

    RECRUITING

    Daegu, 42415, South Korea

  • Site Number - 4501

    RECRUITING

    Seoul, 02841, South Korea

  • Site Number - 4503

    RECRUITING

    Goyang, 410-77, South Korea

  • Site Number - 4504

    RECRUITING

    Guri-si, 11923, South Korea

  • Site Number - 4505

    RECRUITING

    Seoul, 05278, South Korea

  • Site Number - 4506

    RECRUITING

    Seoul, 03181, South Korea

  • Site Number - 4507

    RECRUITING

    Seoul, 6591, South Korea

  • Site Number - 4508

    RECRUITING

    Seoul, 03080, South Korea

  • Site Number - 4600

    RECRUITING

    Ogre, LV-5001, Latvia

  • Site Number - 4601

    RECRUITING

    Ventspils, LV-3601, Latvia

  • Site Number - 4602

    RECRUITING

    Riga, LV-1006, Latvia

  • Site Number - 4603

    RECRUITING

    Riga, LV-1050, Latvia

  • Site Number - 4604

    RECRUITING

    Sigulda, LV-2150, Latvia

  • Site Number - 4605

    RECRUITING

    Riga, LV-1002, Latvia

  • Site Number - 5100

    RECRUITING

    Southport, Queensland, 4222, Australia

  • Site Number - 5101

    RECRUITING

    Brisbane, Queensland, 4101, Australia

  • Site Number - 5102

    RECRUITING

    Box Hill, Victoria, 3128, Australia

  • Site Number - 5103

    RECRUITING

    Warrawong, New South Wales, 2502, Australia

  • Site Number - 5104

    RECRUITING

    Geelong, Victoria, 3220, Australia

  • Site Number - 5105

    RECRUITING

    Sydney, New South Wales, 2050, Australia

  • Site Number - 5107

    RECRUITING

    Douglas, Queensland, 4814, Australia

  • Site Number - 5108

    RECRUITING

    Perth, 6009, Australia

  • Site Number - 5109

    RECRUITING

    Saint Leonards, 2065, Australia

  • Site Number - 5110

    RECRUITING

    Parkville, Victoria, 3050, Australia

  • Site Number - 5500

    RECRUITING

    Campinas, São Paulo, 09060-870, Brazil

  • Site Number - 5501

    RECRUITING

    Porto Alegre, 90035903, Brazil

  • Site Number - 5502

    RECRUITING

    Brasília, 70200-730, Brazil

  • Site Number - 5503

    RECRUITING

    Curitiba, 80060-240, Brazil

  • Site Number - 5504

    RECRUITING

    Curitiba, 80810040, Brazil

  • Site Number - 5505

    RECRUITING

    Santo André, São Paulo, 09060-870, Brazil

  • Site Number - 5506

    RECRUITING

    São Paulo, 01221-020, Brazil

  • Site Number - 5507

    RECRUITING

    São Paulo, 15500-003, Brazil

  • Site Number - 5508

    RECRUITING

    São Paulo, 01228-000, Brazil

  • Site Number - 5509

    RECRUITING

    São Paulo, 17504-072, Brazil

  • Site Number - 5510

    RECRUITING

    São Paulo, 05403-000, Brazil

  • Site Number - 5511

    RECRUITING

    Fortaleza, Ceará, 21941-913, Brazil

  • Site Number - 5512

    RECRUITING

    Rio de Janeiro, 21941-913, Brazil

  • Site Number - 5513

    RECRUITING

    Belo Horizonte, Minas Gerais, 30150-320, Brazil

  • Site Number - 5600

    RECRUITING

    Yambol, 8600, Bulgaria

  • Site Number - 5601

    RECRUITING

    Sliven, 8800, Bulgaria

  • Site Number - 5602

    RECRUITING

    Varna, 9002, Bulgaria

  • Site Number - 5603

    RECRUITING

    Varna, 9020, Bulgaria

  • Site Number - 5604

    RECRUITING

    Sofia, 1233, Bulgaria

  • Site Number - 5606

    RECRUITING

    Plovdiv, 4001, Bulgaria

  • Site Number - 5607

    RECRUITING

    Plovdiv, 4002, Bulgaria

  • Site Number - 5608

    RECRUITING

    Sofia, 1680, Bulgaria

  • Site Number - 5609

    RECRUITING

    Sofia, 1431, Bulgaria

  • Site Number - 5610

    RECRUITING

    Sofia, Sofia-Grad, 1431, Bulgaria

  • Site Number - 5611

    RECRUITING

    Varna, 9020, Bulgaria

  • Site Number - 5612

    RECRUITING

    Smolyan, 4700, Bulgaria

  • Site Number - 5613

    RECRUITING

    Dobrich, 7002, Bulgaria

  • Site Number - 5700

    RECRUITING

    Santiago, 7690000, Chile

  • Site Number - 5701

    RECRUITING

    Santiago, 8380456, Chile

  • Site Number - 6001

    RECRUITING

    Rome, 135, Italy

  • Site Number - 6002

    RECRUITING

    Udine, 33100, Italy

  • Site Number - 6003

    RECRUITING

    Milan, 20132, Italy

  • Site Number - 6004

    RECRUITING

    Bergamo, 24127, Italy

  • Site Number - 6005

    RECRUITING

    Rozzano, Milan, 20089, Italy

  • Site Number - 6006

    RECRUITING

    Pavia, 27100, Italy

  • Site Number - 6007

    RECRUITING

    Bergamo, 168, Italy

  • Site Number - 6010

    RECRUITING

    Rome, 128, Italy

  • Site Number - 6011

    RECRUITING

    Livorno, 57124, Italy

  • Site Number - 6012

    RECRUITING

    Torino, 10128, Italy

  • Site Number - 6013

    RECRUITING

    Acquaviva delle Fonti, 70021, Italy

  • Site Number - 6014

    RECRUITING

    Naples, 80131, Italy

  • Site Number - 6015

    RECRUITING

    Cuneo, 12100, Italy

  • Site Number - 7001

    RECRUITING

    London, W2 1NY, United Kingdom

  • Site Number - 7003

    RECRUITING

    Merthyr Tydfil, CF72 8XR, United Kingdom

  • Site Number - 7006

    RECRUITING

    London, SE1 9RT, United Kingdom

  • Site Number - 7008

    RECRUITING

    Surrey, GU2 7XX, United Kingdom

  • Site Number - 7009

    RECRUITING

    Cornwell, TR1 3LJ, United Kingdom

  • Site Number - 7010

    RECRUITING

    Salford, M6 8HD, United Kingdom

  • Site Number - 7102

    RECRUITING

    Madrid, 28040, Spain

  • Site Number - 8000

    RECRUITING

    Tbilisi, 0145, Georgia

  • Site Number - 8001

    RECRUITING

    Tbilisi, 0160, Georgia

  • Site Number - 8002

    RECRUITING

    Tbilisi, 0159, Georgia

  • Site Number - 8003

    RECRUITING

    Tbilisi, 0114, Georgia

  • Site Number - 8004

    RECRUITING

    Imereti, 4600, Georgia

  • Site Number - 8005

    RECRUITING

    Tbilisi, 0186, Georgia

  • Site Number -1014

    RECRUITING

    Concord, California, 94520, United States

  • Site Number -1023

    RECRUITING

    Irving, Texas, 75031, United States

  • Site Number- 5605

    RECRUITING

    Sofia, 1750, Bulgaria

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