GRAFT VS HOST DISEASE

This study tests whether adding the drug vorinostat to standard care can lower the chance of graft-versus-host disease (GVHD) in children, teens, and young adults getting a bone marrow or blood stem cell transplant for blood cancers. About 43 participants will receive vorinostat …

This study tests a new combination of drugs to prevent graft-versus-host disease (GVHD) in 27 adults receiving a stem cell transplant from a half-matched donor. The goal is to see if using lower doses of certain immune-suppressing drugs can still prevent GVHD while causing fewer …

This study tests a device that filters out certain immune cells from donor blood before a stem cell transplant. The goal is to lower the risk of graft-versus-host disease, a serious complication where the donor cells attack the patient's body. About 50 adults with myelodysplastic…

This study offers ongoing access to ibrutinib for 297 people with certain blood cancers or graft-versus-host disease who completed earlier ibrutinib trials and still benefit from the drug but cannot get it commercially. Participants continue their current treatment while research…

This study tests a new imaging device called MSOT that uses light and sound to detect inflammation in the skin or gut. Researchers will check if it is safe and can spot inflammation in people with graft-versus-host disease, Crohn's disease, or colitis. About 100 adults will have …

This study looks at whether 30 sessions of UVA-1 light therapy can improve how people with scleroderma, morphea, or skin-related graft-versus-host disease feel and function in daily life. About 30 adults will receive the treatment and report their symptoms using questionnaires. T…

This study looks at whether a group-based program called Horizons can help adults with chronic graft-versus-host disease (cGVHD) improve their quality of life and coping skills. About 20 people who had a stem cell transplant and now have moderate to severe cGVHD will take part. T…

This study tests a special program called Horizons for adults who have had a stem cell transplant and developed chronic graft-versus-host disease (GVHD). The program includes group sessions to help patients cope with symptoms, improve quality of life, and take their medications a…

This study aims to better understand immune-related gut diseases like inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), and functional gut disorders. Researchers will collect blood and tissue samples from 1,000 patients to analyze immune cells and find what driv…

This study involves 383 people who have chronic Graft-versus-Host Disease (GVHD) after a stem cell transplant. Researchers are developing and testing new measurement tools to more accurately determine if a patient is responding to treatment. The goal is to better predict which th…