GRAFT VS HOST DISEASE

This study tested a new approach to prevent graft-versus-host disease (GVHD), a serious complication that can occur after a stem cell transplant. Researchers combined the drug pacritinib with two standard immune-suppressing medicines (sirolimus and tacrolimus) in 40 adults receiv…

This study tested whether adding the drug abatacept to standard medications (calcineurin inhibitor and methotrexate) could better prevent severe acute graft-versus-host disease (aGVHD) after a stem cell transplant from an unrelated donor. The trial included 186 participants aged …

This study looked at whether giving liver transplant patients lower doses of immune-suppressing drugs could reduce the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the recipient's body. The study involved 100 adults who received a live…

This small pilot study tested whether the drug belimumab (Benlysta) could safely prevent chronic graft-versus-host disease (GvHD) in 10 adults who had a stem cell transplant for blood cancer. Chronic GvHD is a serious condition where donor immune cells attack the patient's body. …

This study tested adding the drug ruxolitinib to standard steroid treatment for children aged 28 days to under 18 years who had moderate to severe chronic graft-versus-host disease (cGvHD) after a stem cell transplant. cGvHD is a condition where donor immune cells attack the chil…

This study tested a drug called pomalidomide in 34 adults with chronic graft-versus-host disease (GvHD), a condition where donor immune cells attack the recipient's body after a stem cell transplant. Participants had GvHD that did not improve with standard treatments. They took p…

This study tested whether a drug called obinutuzumab can prevent chronic graft-versus-host disease (cGVHD), a common and serious complication after a stem cell transplant. The trial involved 181 people who had received a stem cell transplant from a donor. The main goal was to see…