GRAFT-VERSUS-HOST-DISEASE
Clinical trials for GRAFT-VERSUS-HOST-DISEASE explained in plain language.
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New drug cocktail aims to tame deadly transplant complication
Disease control Recruiting nowThis early-phase study tests whether two drugs, ruxolitinib and abatacept, can prevent graft-versus-host disease (GVHD) and cytokine release syndrome in people receiving a half-matched stem cell transplant for blood cancers. About 41 participants will take the drugs before and af…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE1 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated May 26, 2026 10:37 UTC
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New drug may prevent lymphoma relapse after transplant
Disease control Recruiting nowThis study tests whether the drug ruxolitinib can help prevent T-cell lymphoma from returning and reduce graft-versus-host disease (GVHD) after a stem cell transplant. About 44 adults with T-cell lymphoma who are in remission after transplant will take ruxolitinib as a maintenanc…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE2 • Sponsor: Jonathan Brammer • Aim: Disease control
Last updated May 26, 2026 10:36 UTC
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New device aims to make stem cell transplants safer for kids
Disease control Recruiting nowThis study tests a device that removes certain immune cells from donated stem cells before transplant. The goal is to lower the risk of graft-versus-host disease, a serious complication where donor cells attack the patient's body. Up to 90 children and young adults (ages 0-30) wi…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: NA • Sponsor: Christopher Dvorak • Aim: Disease control
Last updated May 26, 2026 10:35 UTC
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New hope for stem cell patients: simpler drug combo may cut severe side effects
Disease control Recruiting nowThis study tests whether a single drug (cyclophosphamide) given after a stem cell transplant can prevent graft-versus-host disease (GVHD) as well as standard multiple-drug approaches. About 82 adults with blood cancers will receive one of two conditioning regimens before transpla…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE2 • Sponsor: Nantes University Hospital • Aim: Disease control
Last updated May 26, 2026 10:32 UTC
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New hope for transplant patients: experimental drug targets stubborn graft-versus-host disease
Disease control Recruiting nowThis study tests a new drug, rovadicitinib, for people with moderate to severe chronic graft-versus-host disease (cGVHD) after a stem cell transplant. Participants have already tried 2 to 5 other treatments. The goal is to see if rovadicitinib improves symptoms better than standa…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE3 • Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. • Aim: Disease control
Last updated May 26, 2026 10:32 UTC
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New drug combo aims to tame immune attack after stem cell transplant
Disease control Recruiting nowThis early-phase trial tests whether adding emapalumab to standard medications can safely prevent graft-versus-host disease (GVHD) in 15 adults with leukemia or myelodysplastic syndrome receiving a reduced-intensity donor stem cell transplant. Emapalumab blocks a protein that dri…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 26, 2026 10:30 UTC
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New drug combo aims to prevent transplant complications
Disease control Recruiting nowThis early-stage study tests whether adding a drug made from urine (uhCG/EGF) to standard care can safely prevent graft-versus-host disease (GVHD) in stem cell transplant patients. GVHD is a serious condition where donor cells attack the patient's body. The study involves 18 adul…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE1 • Sponsor: Henry Ford Health System • Aim: Disease control
Last updated May 26, 2026 10:26 UTC
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Cord blood transplants offer new hope for young blood cancer patients
Disease control Recruiting nowThis study tests whether a cord blood transplant (using stem cells from donated umbilical cord blood) can help children and young adults up to age 26 with blood cancers like leukemia or lymphoma. Participants receive the transplant as their first or second treatment. The main goa…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated May 26, 2026 10:26 UTC
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New drug aims to stop deadly immune attack after stem cell transplant
Disease control Recruiting nowThis study tests an experimental drug called BPC2001 to prevent acute graft-versus-host disease (aGVHD) in 50 adults receiving a half-matched stem cell transplant for blood cancers. Participants get BPC2001 plus standard care, and researchers track how many develop aGVHD by day 1…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE2 • Sponsor: BioPhoenix Co., Ltd. • Aim: Disease control
Last updated May 22, 2026 14:01 UTC
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New drug combo aims to prevent transplant complications in blood cancer patients
Disease control Recruiting nowThis study tests whether adding the drug belumosudil to standard care can better prevent graft-versus-host disease (GVHD) in adults with blood cancer who have had a stem cell transplant. About 46 participants will receive belumosudil alongside their usual GVHD prevention medicine…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated May 20, 2026 11:53 UTC
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Could a lower dose of transplant drug be just as effective?
Disease control Recruiting nowThis study compares a reduced dose (35mg/kg) versus the standard dose (50mg/kg) of a drug called cyclophosphamide, given after a stem cell transplant to prevent graft-versus-host disease (GVHD). About 316 people receiving a transplant from a matched unrelated or half-matched dono…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE3 • Sponsor: Shanghai Jiao Tong University School of Medicine • Aim: Disease control
Last updated May 08, 2026 12:03 UTC
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Bone marrow cells injected into glands may offer dry mouth relief
Symptom relief Recruiting nowThis early-phase trial tests whether injecting special bone marrow cells (called mesenchymal stromal cells) into the salivary glands is safe and can improve dry mouth. The study includes 36 adults with dry mouth not caused by radiation, such as from Sjogren's disease or graft-ver…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE1 • Sponsor: University of Wisconsin, Madison • Aim: Symptom relief
Last updated May 26, 2026 10:37 UTC
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Light therapy offers hope for stem cell transplant survivors with chronic mouth pain
Symptom relief Recruiting nowThis study tests a light-based treatment called photobiomodulation (PBM) for people who have painful mouth sores from chronic graft-versus-host disease (GVHD) after a stem cell transplant. About 44 participants will receive either real PBM or a placebo treatment to see if the lig…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Symptom relief
Last updated May 26, 2026 10:35 UTC
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New telehealth program aims to boost quality of life for stem cell transplant survivors
Symptom relief Recruiting nowThis study tests a group-based telehealth program called HORIZONS for adults who have chronic graft-versus-host disease after a stem cell transplant. The program is designed to help patients better manage their condition and improve their quality of life. Researchers will compare…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated May 26, 2026 10:23 UTC
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Ancient heat therapy may ease Life-Threatening transplant complication
Symptom relief Recruiting nowThis study tests whether moxibustion—a traditional therapy that burns herbs near the skin—can help people with severe gut problems after a stem cell transplant. About 42 patients whose graft-versus-host disease did not respond to steroids will receive standard drugs plus daily mo…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE2 • Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology • Aim: Symptom relief
Last updated May 22, 2026 14:05 UTC
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New lung scan method could predict transplant complications
Knowledge-focused Recruiting nowThis study looks at whether a special lung scan (parametric response mapping) can help detect chronic lung injury early in people who have had a blood stem cell transplant. Researchers will follow 375 patients for one year to see if the scan can predict lung problems or death. Th…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Sponsor: University of Michigan Rogel Cancer Center • Aim: Knowledge-focused
Last updated May 26, 2026 10:38 UTC
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New study tracks oral clues to transplant complication
Knowledge-focused Recruiting nowThis study follows people who have had or will soon have a stem cell transplant from a donor. It aims to understand how chronic graft-versus-host disease (cGVHD) affects the mouth. Researchers will collect dental exams, saliva, mouth swabs, and photos over three years. Healthy vo…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Sponsor: National Institute of Dental and Craniofacial Research (NIDCR) • Aim: Knowledge-focused
Last updated May 26, 2026 10:26 UTC
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Gut check: can diet predict transplant complications?
Knowledge-focused Recruiting nowThis study looks at how certain carbohydrates (FODMAPs) in the diet are broken down by gut bacteria and whether that relates to graft-versus-host disease (GVHD) after a bone marrow transplant. Researchers will follow 100 patients who have had a successful transplant to track when…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Sponsor: The First Affiliated Hospital of Soochow University • Aim: Knowledge-focused
Last updated May 22, 2026 13:54 UTC
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Healthy donors help scientists make bone marrow transplants safer
Knowledge-focused Recruiting nowThis study collects blood stem cells from 500 healthy volunteers to develop better ways to process them for transplants. The goal is to remove the white blood cells that can cause a serious complication called graft-versus-host disease while keeping the stem cells needed for reco…
Matched conditions: GRAFT-VERSUS-HOST-DISEASE
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated May 18, 2026 12:07 UTC