GERM CELL TUMOR

This study tests a mix of four drugs (vorinostat, vincristine, irinotecan, and temozolomide) in children, teens, and young adults up to age 30 whose solid tumors or brain cancers have returned or not responded to standard treatment. The main goal is to find the safest dose of vor…

This study looks at two groups of people with germ cell tumors. For those with low-risk tumors that haven't spread, doctors will simply monitor them closely after surgery instead of giving extra treatment. For standard-risk patients whose tumors have spread, the study compares tw…

This study tests whether taking two drugs (zanzalintinib and oral etoposide) after high-dose chemotherapy can help keep relapsed germ cell tumors from growing back. About 38 adults whose cancer has not been cured by standard treatments will receive this maintenance therapy. The g…

This early-stage study tests a new drug called ZW251 in about 100 people with advanced liver, lung, or germ cell cancers that have not responded to other treatments. ZW251 is designed to deliver a cancer-killing agent directly to tumor cells that carry a specific marker (GPC3). T…

This early-stage study tests a new drug called XmAb541 in people with advanced ovarian, endometrial, or germ cell tumors that have not responded to prior treatments. The main goals are to check if the drug is safe and to find the best dose. About 282 participants will take part i…

This study tests a combination of two chemotherapy drugs, teniposide and cisplatin, in 40 people newly diagnosed with a rare type of brain tumor called central malignant germ cell tumor. The goal is to see how well the treatment shrinks tumors and to find markers that predict res…

This early-stage study is testing whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG or recurrent medulloblastoma. The cells are designed to recogn…

This study is testing whether a safe green dye, called ICG, can help surgeons see which lymph nodes might contain cancer in children with solid tumors. About 10 children will receive the dye during surgery, and doctors will check if it makes the right lymph nodes glow. The goal i…

This study tests a new robot-assisted technique that uses a special dye (ICG) to find if testicular cancer has spread to nearby lymph nodes. Current methods often miss small cancer deposits, leading to either undertreatment or overtreatment. The goal is to see if this approach ca…

This study tests whether taking a daily low-dose aspirin can prevent blood clots in people with advanced germ cell tumors (including testicular cancer) who are receiving standard chemotherapy. About 35 participants will take aspirin alongside their chemo for 26 weeks. The goal is…

This study watches 1650 people with different types of brain tumors to see if the new 2021 classification system helps doctors choose better treatments. Researchers will track how long patients live and how well their tumors respond to therapy. The goal is to create clearer treat…

This study creates a registry of people with germ cell or testicular tumors, along with their relatives and unrelated volunteers. By collecting medical and family history, researchers hope to understand why some people develop these tumors and others don't. The goal is to improve…

This study follows over 1,100 children and teens diagnosed with germ cell tumors to learn about short- and long-term side effects from treatment, especially hearing loss. Researchers will also analyze tumor genetics to find patterns that could better predict which patients need m…