GERM CELL TUMOR
Clinical trials for GERM CELL TUMOR explained in plain language.
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New hope for incurable germ cell tumors? cabozantinib trial underway
Disease control OngoingThis study tests the drug cabozantinib in 50 adults with germ cell tumors (like testicular or ovarian cancer) that have not responded to standard chemotherapy. The goal is to see if the drug can shrink tumors or stop them from growing for at least 3 months. Participants will take…
Matched conditions: GERM CELL TUMOR
Phase: PHASE2 • Sponsor: Jennifer King • Aim: Disease control
Last updated May 26, 2026 07:38 UTC
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Immune cells engineered to fight childhood cancers enter first human tests
Disease control OngoingThis early-phase study tests a new treatment for children and young adults (up to age 26) with solid tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a protein c…
Matched conditions: GERM CELL TUMOR
Phase: PHASE1 • Sponsor: Seattle Children's Hospital • Aim: Disease control
Last updated May 26, 2026 07:32 UTC
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Immunotherapy duo takes on stubborn germ cell tumors
Disease control OngoingThis study tests two immunotherapy drugs, durvalumab and tremelimumab, in 30 adults with germ cell tumors that have come back or not responded to standard treatment. The goal is to see if the combination can shrink tumors and control the disease. Participants must have measurable…
Matched conditions: GERM CELL TUMOR
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated May 26, 2026 07:23 UTC
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Proton beam therapy aims to shrink brain tumors with fewer side effects
Disease control OngoingThis study looks at whether proton beam radiation can safely treat germ cell tumors in the brain and spine while causing fewer side effects than standard photon radiation. About 45 participants aged 3 to 25 will receive proton therapy. The goal is to control the tumor and track b…
Matched conditions: GERM CELL TUMOR
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated May 22, 2026 14:04 UTC
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Engineered immune cells take aim at childhood cancers in early trial
Disease control OngoingThis early-phase study tests a personalized cell therapy for children and young adults (ages 1–30) whose solid tumors have come back or not responded to standard treatment. Researchers take a patient's own immune T cells, modify them to recognize and attack cancer cells that carr…
Matched conditions: GERM CELL TUMOR
Phase: PHASE1 • Sponsor: Seattle Children's Hospital • Aim: Disease control
Last updated May 22, 2026 13:54 UTC
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Engineered immune cells injected directly into brain show promise for kids with cancer
Disease control OngoingThis early-stage study tests whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with HER2-positive brain tumors that have come back or not responded to standard treatments. The cells are…
Matched conditions: GERM CELL TUMOR
Phase: PHASE1 • Sponsor: Seattle Children's Hospital • Aim: Disease control
Last updated May 11, 2026 20:40 UTC
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Surviving rare ovarian cancer: what comes next? new study investigates hidden toll of treatment
Knowledge-focused OngoingThis study looks at women who have recovered from rare ovarian cancers (germ cell or sex cord-stromal tumors) to understand how chemotherapy affects their long-term health and daily life. Researchers will compare those who had chemotherapy plus surgery with those who had surgery …
Matched conditions: GERM CELL TUMOR
Phase: NA • Sponsor: Centre Francois Baclesse • Aim: Knowledge-focused
Last updated May 26, 2026 07:40 UTC
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Blood marker may predict cancer return in testicular cancer patients
Knowledge-focused OngoingThis study is testing whether a blood marker called miRNA 371 can predict if germ cell tumors (a type of cancer) will return after treatment. Researchers will collect blood samples from 956 newly diagnosed patients and track their health over time. The goal is to see if this mark…
Matched conditions: GERM CELL TUMOR
Sponsor: SWOG Cancer Research Network • Aim: Knowledge-focused
Last updated May 26, 2026 07:24 UTC