GASTROINTESTINAL STROMAL TUMORS

This study tests the chemotherapy drug temozolomide in people with advanced gastrointestinal stromal tumors (GIST) that lack a key enzyme called SDH. About 29 adults will receive the drug to see if it shrinks tumors and is safe. The goal is to control the disease, not cure it.

This study tests an oral form of paclitaxel (Liporaxel) in 28 adults with advanced gastrointestinal stromal tumors (GIST) that no longer respond to three standard drugs (imatinib, sunitinib, regorafenib). Only patients whose tumors have low levels of a protein called P-glycoprote…

This early-phase study tests a new drug called NN3201, designed to find and attack cancer cells that have a specific protein called c-Kit. The trial includes people with advanced or spreading cancers like gastrointestinal stromal tumors (GIST), small-cell lung cancer, and others.…

This study tests whether DNA changes in the KIT gene can help doctors choose the right drug for people with advanced gastrointestinal stromal tumor (GIST). About 48 adults who have already tried imatinib will receive either sunitinib or regorafenib based on their tumor's DNA. The…

This early-phase study tests whether adding fampridine to the standard drug imatinib is safe and effective for people with a specific type of gastrointestinal stromal tumor (GIST) that has a KIT gene mutation. About 18 participants will take the drugs for at least 2 months before…

This study tests a combination of two drugs, rivoceranib and paclitaxel, in people with advanced gastrointestinal stromal tumors (GIST) that have a specific marker (high P-glycoprotein) and have stopped responding to three standard treatments. The goal is to see if this combo can…

This study tests whether regularly checking the amount of imatinib in the blood can help reduce side effects and improve quality of life for people with gastrointestinal stromal tumors (GIST). About 28 adults who are starting or recently started imatinib will have their drug leve…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study looks at whether follow-up care for people with rare tumors can be done just as well by a nurse remotely as by a doctor in person. About 88 adults recently diagnosed with a rare tumor will be randomly assigned to either in-person doctor visits or remote nurse check-ins…