GASTROINTESTINAL STROMAL TUMORS

This early-phase study tests adding fampridine to standard imatinib (Gleevec) in 18 adults with a specific type of GIST tumor. Participants take the drugs for at least 2 months before surgery to find the safest dose and see if the combination shrinks tumors. The goal is to improv…

This phase 2 trial tests an oral form of paclitaxel (Liporaxel) in 28 adults with advanced gastrointestinal stromal tumors (GIST) that no longer respond to three standard drugs: imatinib, sunitinib, and regorafenib. The study focuses on patients whose tumors have low levels of a …

This phase 2 trial tests a combination of two drugs—rivoceranib and paclitaxel—in 48 adults with advanced gastrointestinal stromal tumors (GIST) that have a specific protein marker (high P-glycoprotein) and have stopped responding to three standard treatments. The goal is to see …

This study tests the drug temozolomide in people with a rare type of advanced stomach cancer called SDH-deficient GIST. About 29 adults will receive the drug to see if it shrinks tumors and is safe. The goal is to control the disease, not cure it.

This early-stage trial tests a new drug called NN3201 in people with advanced cancers that have a specific marker called c-Kit. The drug is designed to deliver a chemotherapy agent directly to cancer cells, potentially killing them while sparing healthy tissue. The study will enr…

This phase 2 trial tests whether DNA changes in the KIT gene can predict how well patients with advanced gastrointestinal stromal tumor (GIST) respond to two standard drugs, sunitinib and regorafenib. About 48 adults whose GIST has worsened on imatinib will receive the drugs in s…

This study tests whether regularly checking imatinib levels in the blood can reduce side effects and improve quality of life for people with gastrointestinal stromal tumors (GIST). About 28 adults starting or recently starting imatinib will participate. The goal is to see if this…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study looks at whether follow-up care for people with rare tumors can be done just as well by a nurse remotely as by a doctor in person. About 88 adults recently diagnosed with a rare tumor will be randomly assigned to either in-person doctor visits or remote nurse check-ins…