GASTRIC ADENOCARCINOMA

This study tests whether giving heated chemotherapy directly into the abdomen during surgery can prevent stomach or gastroesophageal cancer from coming back in the belly lining. It is for 16 adults with high-risk cancer. The approach aims to kill any stray tumor cells that might …

This study tests whether giving two immunotherapy drugs (nivolumab and ipilimumab) along with chemotherapy and radiation before surgery can help treat stomach cancer that is still removable. About 32 adults with early-stage stomach or gastroesophageal junction cancer will receive…

This study looks at whether using just one or a few small cuts (single or reduced ports) for laparoscopic stomach cancer surgery is safe and works well. It involves 108 people with advanced stomach cancer. The main goal is to see how many lymph nodes can be removed, and the study…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation before and after surgery can help prevent stomach cancer from coming back. It is for people with specific genetic types of stomach cancer (mismatch repair deficient or Epst…

This study compares a new esophageal stent (Luso-Cor) with standard stents and vacuum therapy for closing leaks that can happen after weight-loss or cancer surgery on the stomach or esophagus. About 180 adults who develop these leaks will be enrolled. The goal is to see which met…

This study tests a new drug called ASKB589 added to standard chemotherapy and immunotherapy for people with advanced stomach or gastroesophageal junction cancer that has a specific marker (CLDN18.2). The goal is to see if the combination helps keep the cancer from growing longer …

This study tests whether adding the drug tucatinib to standard treatments (like trastuzumab and chemotherapy) is safe for people with HER2-positive cancers of the digestive system. About 40 adults with advanced cancer of the colon, stomach, esophagus, or gallbladder will receive …

This early-phase trial tests whether a shorter course (2 weeks instead of 5) of chemoradiotherapy followed by standard chemotherapy is safe and effective for people with stomach cancer who will have surgery. About 25 participants will receive the shorter radiation plus chemo befo…

This study tests whether adjusting chemotherapy doses based on a patient's genetics can improve outcomes for people with advanced stomach or esophageal cancer that has spread to nearby tissues or lymph nodes. About 36 participants will receive a chemotherapy regimen called mFOLFI…

This study tests a new drug called SKB264 in people with advanced solid tumors (like lung, breast, or ovarian cancer) that have not improved with standard treatments. The goal is to find the best dose and see if it can shrink tumors. About 1,410 participants will receive the drug…

This study tests whether the immunotherapy drug atezolizumab, alone or with chemotherapy, can shrink or control a specific type of stomach or gastroesophageal junction cancer that has a high number of genetic mutations (MSI-H/dMMR). About 240 adults with early-stage but resectabl…

This study tests whether a combination of targeted drugs (trastuzumab deruxtecan, capecitabine, and durvalumab) can shrink HER2-positive stomach or gastroesophageal junction cancer before surgery and prevent return after surgery. About 64 adults with untreated, advanced but not s…

This study tests a special recovery plan for people with stomach cancer who need surgery. The plan focuses on reducing pain and nausea, helping the bowels work sooner, and shortening hospital stays. About 52 patients with early to advanced stomach cancer will take part to see if …

This study looks at whether using a small camera to look inside the belly (laparoscopy) helps doctors choose better treatments for people with stage III stomach cancer. About 968 adults with stomach cancer will be randomly assigned to get this extra procedure or not. The goal is …

This study follows 208 adults in France with advanced or metastatic stomach, gastroesophageal junction, or esophageal cancer who are receiving nivolumab combined with chemotherapy as their first treatment. The main goal is to see how long patients live in real-world conditions. R…

This study looks back at hospital records to understand the extra costs of adding an upper stomach endoscopy when people already get a colonoscopy for colorectal cancer screening. It also examines the overall economic burden of treating stomach cancer. About 250 adults aged 50–75…

This study examines whether men and women with stomach cancer receive different care in Germany. Researchers will analyze data from 75,000 patients treated between 2017 and 2021, looking at survival rates, complications, and treatment approaches. The goal is to identify gender-ba…