GASTRIC ADENOCARCINOMA

This study tests two different drug combinations given before surgery for people with a specific genetic type of stomach or gastroesophageal junction cancer (dMMR/MSI-H). The goal is to see if these treatments can completely eliminate the tumor before it is removed. About 30 adul…

This study tests whether injecting a new treatment called RP2 directly into tumors, along with standard chemotherapy (FLOT), is safe and works better than chemotherapy alone before surgery. It involves 34 adults with stage 2 or higher stomach or esophagus cancer that hasn't sprea…

This phase 3 trial tests whether adding the experimental drug JS107 to standard chemo and immunotherapy works better than another immunotherapy combo for people with advanced stomach or gastroesophageal junction cancer that has a specific marker (CLDN18.2). About 600 adults who h…

This study tests whether adding the drugs SHR-1701 and apatinib to standard chemotherapy before surgery can improve outcomes for people with locally advanced stomach or gastroesophageal junction cancer. About 80 adults will be randomly assigned to receive either SHR-1701 plus che…

This study tests a new drug called BHB810 in adults with advanced stomach or gastroesophageal junction cancer that has not responded to standard treatments. The drug is given as an IV infusion every two weeks. The main goals are to check safety, find the best dose, and see if it …

This study tests a combination of three drugs (disitamab vedotin, tunlametinib, and a PD-1 antibody) in people with advanced HER2-positive gastric cancer who have already tried at least two other treatments. The goal is to see if this combo can shrink tumors and how safe it is. A…

This is the first human study of an experimental oral drug called ACC-1898 for adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and understand how the body processes the drug. Participants will take dail…

This study tests whether a low dose of olanzapine, a drug often used for nausea, can help people with stomach cancer maintain their weight and appetite while receiving chemotherapy before surgery. About 26 participants will be randomly assigned to receive either olanzapine plus s…

This study tests whether a personalized exercise program, tracked by a smartwatch, can help reduce fatigue in people who have finished chemotherapy for certain cancers. About 98 adults will be randomly assigned to either the exercise program or standard follow-up. The main goals …

This study will follow 3000 adults aged 40 and older who are at high risk for stomach cancer. Participants will provide a stool sample and have a normal stomach exam at the start. Researchers will track who develops stomach cancer over 10 years to see if the stool test can predic…

This early-phase study tests whether a magnetic tracer and a fluorescent dye can safely help doctors find lymph nodes where stomach cancer may have spread. About 20 adults with early-stage stomach cancer will receive the tracer before their surgery. The goal is to see if this met…

This study will look at 4,000 adults aged 40 and older in India who are already scheduled for an upper endoscopy. Doctors will use high-definition cameras and tissue samples to count how many have early stomach cancer or precancerous changes. The goal is to understand how common …