ESOPHAGEAL CARCINOMA

This study looks at people with esophageal or stomach cancer that has spread to only a few spots in the body. After 4 months of standard chemotherapy, some will get local treatment (surgery or radiation) right away, while others will have 4 more months of chemo first. The goal is…

This study tests whether adding immunotherapy to a special type of radiation (that spares key immune nodes) plus chemotherapy can help adults with advanced esophageal cancer live longer without the disease getting worse. About 432 participants will receive either the full combo o…

This study tests whether adding immunotherapy (a PD-1 inhibitor) after standard chemotherapy and radiation can help control advanced esophageal cancer for longer. About 452 adults with a specific type of esophageal cancer will receive either immunotherapy or monitoring after init…

This study tests whether the heart medication amiodarone can prevent atrial fibrillation (an irregular, often rapid heartbeat) in people recovering from minimally invasive esophageal cancer surgery. Atrial fibrillation is the most common complication after this surgery, and there…

This study tests a new tool called the PAGODA algorithm to help doctors adjust chemotherapy doses proactively. The goal is to reduce unplanned treatment delays in people with gastrointestinal cancers receiving FOLFOX chemotherapy. About 420 participants will be randomly assigned …

This study tests whether a program of exercise and nutrition supplements before esophageal cancer surgery is practical and helpful for patients. Twenty adults scheduled for surgery will either receive the pre-surgery program or standard care. Researchers will measure how many pat…

This study tests whether giving the cancer drug nivolumab as a shot at home is as safe and effective as getting it in a clinic. About 50 adults with various cancers will try both settings to see which they prefer and how it affects their quality of life. The goal is to reduce the…

This study tests whether a special yoga program can improve physical function, fatigue, sleep, and quality of life for people with lung or esophageal cancer who are getting radiation therapy, and also for their family caregivers. About 400 patient-caregiver pairs will take part. …

This study is testing new blood tests that look for signs of many different cancers at the same time. The goal is to see if these tests can find cancer early, when treatment works best. About 24,000 adults aged 45 to 75 who do not have cancer will take part. They will be placed i…

This study is gathering information on side effects from proton therapy in 5,000 adults with various cancers. Researchers will collect detailed treatment and toxicity data to better understand and predict short- and long-term side effects. The goal is to improve future patient ca…

This early-phase study tests whether a new radioactive tracer can help doctors see tumors on PET/CT scans. About 32 adults with different solid tumors will receive a single injection of the tracer. The goal is to understand where the tracer goes in the body, how it is cleared, an…

This study uses special PET/CT scans to see how radiation therapy for lung or esophageal cancer affects the heart. About 20 adults getting radiation will have heart scans before, during, and after treatment. The goal is to learn if these scans can detect heart changes caused by r…