Esophageal adenocarcinoma
Clinical trials for Esophageal adenocarcinoma explained in plain language.
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New drug combo aims to outperform standard immunotherapy in stomach cancer
Disease control CompletedThis phase 3 study tests whether a new combination of two immunotherapy drugs (domvanalimab and zimberelimab) plus chemotherapy works better than the current standard (nivolumab plus chemotherapy) for people with advanced stomach, gastroesophageal junction, or esophageal cancer t…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Phase 3 • Sponsor: Arcus Biosciences, Inc. • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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Targeted drug boosts esophageal cancer treatment in major trial
Disease control CompletedThis phase III trial tested whether adding trastuzumab (Herceptin) to standard chemotherapy and radiation helps people with HER2-positive esophageal cancer. 203 patients were randomly assigned to get chemo and radiation with or without trastuzumab. The study measured how long pat…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Phase 3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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New cocktail of drugs shows promise for Hard-to-Treat stomach cancers
Disease control CompletedThis early-phase trial tested a combination of two targeted drugs (regorafenib and nivolumab) plus standard chemotherapy in 30 adults with advanced or recurrent stomach, gastroesophageal junction, or esophageal adenocarcinoma that could not be surgically removed. The goal was to …
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Phase 1/2 • Sponsor: National Cancer Center Hospital East • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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New hope for advanced gut cancers? early trial tests targeted antibody
Disease control CompletedThis early-stage study tested a new drug called cabotamig in 33 adults with advanced cancers of the digestive system (like colon, pancreas, or liver) that had stopped responding to standard treatments. The goal was to see if the drug is safe and how it affects the body and tumors…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Phase 1 • Sponsor: Arbele Pty Ltd • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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New cancer drug SGN-B6A tested for safety in chinese patients
Disease control CompletedThis early-stage trial tested the safety of a new drug called SGN-B6A in 6 Chinese patients with advanced solid tumors (lung, head and neck, esophageal, stomach cancers). The main goal was to identify side effects and see how the body processes the drug. It is a first step to see…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Phase 1 • Sponsor: Seagen, a wholly owned subsidiary of Pfizer • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Barrett's esophagus treatment showdown: which procedure hurts less?
Disease control CompletedThis study compared two endoscopic treatments for Barrett's esophagus, a condition that can lead to esophageal cancer. The goal was to see which procedure—radiofrequency ablation or hybrid argon plasma coagulation—causes less pain and is safer from the patient's viewpoint. Sixty-…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Sponsor: Centre of Postgraduate Medical Education • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Spray freezing offers quick swallow relief for esophageal cancer patients
Symptom relief CompletedThis pilot study tested whether spray cryotherapy (freezing the tumor from inside the esophagus) can quickly improve swallowing in 15 patients with advanced esophageal cancer who were about to start chemotherapy and radiation. The goal was to ease difficulty swallowing sooner tha…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Sponsor: Hunter Holmes Mcguire Veteran Affairs Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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New scan could predict who benefits from esophageal cancer therapy
Knowledge-focused CompletedThis study explores whether a special PET/MRI scan can predict how well esophageal cancer responds to chemotherapy and radiation given before surgery. Researchers will scan 121 patients during treatment and compare the images with the actual tumor response seen after surgery. The…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Sep 21, 2026 16:00 UTC