ESOPHAGEAL ADENOCARCINOMA

This study is testing if freezing cancerous tissue in the esophagus with liquid nitrogen before standard chemotherapy helps patients more than chemotherapy alone. It will involve 40 adults with locally advanced esophageal cancer who are scheduled to receive chemotherapy. Particip…

This study is testing a new drug, PF-08634404, combined with standard chemotherapy for people with advanced stomach or esophageal cancer that has spread. The goal is to see if this combination is safe and works better than current standard treatments. It is for adults who have no…

This study is testing if a very low dose of radiation can make tumors sensitive again to immunotherapy drugs in patients with advanced esophageal cancer that has stopped responding to standard treatment. About 32 adults who have progressed after first-line chemo-immunotherapy wil…

This study is testing whether injecting an experimental treatment called RP2 directly into stomach or esophagus tumors, along with standard chemotherapy (FLOT), is safe and works better than chemotherapy alone before surgery. Researchers want to see if this combination kills more…

This study is testing if adding the drug itraconazole to the standard heat treatment (ablation) can better prevent esophageal cancer in people with high-risk Barrett's esophagus. It will involve 64 participants who will receive either itraconazole or a placebo pill alongside thei…

This study aims to improve early detection of Barrett's esophagus, a condition that can lead to esophageal cancer. Researchers are testing a combination of an AI-powered risk assessment tool and a less invasive 'sponge on a string' screening test, supported by nurse guidance. The…

This is a very early, small study to see if a single dose of two immunotherapy drugs can change the immune cells inside certain stomach and esophageal tumors. It will involve 34 adults with early-stage cancer who have a specific genetic change (ARID1A mutation) and have not had a…