Esophageal adenocarcinoma

Researchers are testing whether adding an experimental drug called ONO-4578 to nivolumab and chemotherapy helps people with advanced or metastatic gastric cancer, esophagogastric junction cancer, or esophageal adenocarcinoma. The trial enrolls about 600 adults whose tumors are HE…

This study tests whether giving additional chemotherapy after the usual chemoradiation can better control esophageal cancer and reduce the need for surgery. About 60 adults with stage II to IVA esophageal adenocarcinoma will receive chemoradiation followed by more chemotherapy. T…

This study tests a new biologic drug called XYA02 in 190 adults with advanced solid tumors (including lung, ovarian, and pancreatic cancers) that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumo…

This study tests whether injecting a virus called RP2 directly into stomach and esophageal tumors, combined with standard FLOT chemotherapy, is safe and works better than chemotherapy alone before surgery. About 34 people with stage II or higher non-metastatic gastroesophageal ca…

This phase 3 trial will compare two surgical techniques for esophageal cancer: totally minimally invasive esophagectomy (TMIE) using only keyhole incisions, versus a hybrid approach that combines keyhole and open chest surgery. The study aims to see if TMIE reduces severe complic…

This phase II trial tests whether a single low dose of radiation to all visible tumors can help immunotherapy work again in people with advanced esophageal cancer that has stopped responding to standard treatment. Thirty-two adults will receive the radiation and continue their or…

This study will test whether a combination of an AI-powered risk tool, a simple 'sponge on a string' test, and nurse navigation can improve screening for Barrett's esophagus and esophageal cancer. Over 1,000 adults at higher risk will be enrolled. The goal is to see if these less…

This study tests whether using a laryngeal mask instead of a breathing tube during esophageal cancer surgery can reduce complications and speed up recovery. About 500 adults with resectable esophageal cancer will be randomly assigned to one of two anesthesia methods. The goal is …

This study tests whether a personalized blood test (Signatera) can identify gastric cancer patients who, after surgery, have no detectable cancer DNA and can safely receive a milder immunotherapy (durvalumab) instead of standard chemotherapy. About 1000 adults with stage II-IVa g…