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Spray freezing offers quick swallow relief for esophageal cancer patients

NCT ID NCT02606396

Symptom relief Sponsor: Hunter Holmes Mcguire Veteran Affairs Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether spray cryotherapy (freezing the tumor from inside the esophagus) can quickly improve swallowing in 15 patients with advanced esophageal cancer who were about to start chemotherapy and radiation. The goal was to ease difficulty swallowing sooner than standard treatment alone. Patients received cryotherapy during a routine endoscopy, and their symptoms were checked by phone 2 and 4 weeks later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
spray cryotherapy (freezing the tumor from inside the esophagus using an endoscope)
What this could lead to
If it works, this could provide a fast way to ease trouble swallowing in patients with advanced esophageal cancer while they wait for chemotherapy and radiation to take effect.
What could go wrong
This is a very small pilot study with only 15 people, so results may not apply to everyone. The improvement might be minor or temporary, and there are risks from the endoscopy and freezing procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2016

Finished

Mar 2022

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients \>18 years of age with malignant dysphagia due to locally advanced EAC (≥T3 and/or N1) who are undergoing upper endoscopic ultrasound or upper endoscopy for pre-treatment staging or symptom evaluation Exclusion Criteria: * Prior esophageal or gastro-esophageal junction surgery. * Prior diagnosis of oropharyngeal dysphagia. * Prior diagnosis of esophageal achalasia. * Esophageal strictures unrelated to EAC * Distant metastasis * Dysphagia only to solid or semi-solid foods * Need for esophageal dilation in order to pass the diagnostic upper endoscope distal to the tumor. * Coagulopathy (INR\>2, platelets \< 50,000) * Inability to provide informed consent. * Marfan's syndrome

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma Of Esophagus esophageal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Esophageal adenocarcinoma

Contacts and locations

Locations

  • Center for Advanced Medicine

    St Louis, Missouri, 63110, United States

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