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Can a swallowed balloon unlock the genetic secrets of esophageal cancer?

NCT ID NCT00288119

Knowledge-focused Sponsor: Case Western Reserve University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This research study is investigating how genetics and environmental factors contribute to the development of Barrett's esophagus and esophageal adenocarcinoma, a type of cancer. Researchers will collect samples from the esophagus using a non-endoscopic balloon capsule device, which is swallowed and then inflated to gather cells. The study includes adults and children with Barrett's esophagus, esophageal cancer, or a family history of these conditions. The goal is to better understand the biological changes that lead to cancer and to improve detection and risk assessment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Balloon capsule device for esophageal sampling
What this could lead to
If successful, this could lead to better ways to detect and predict progression of Barrett's esophagus to cancer, potentially improving prevention and treatment strategies.
What could go wrong
This is an observational study, so it won't directly test a treatment. The balloon device may not be as accurate as endoscopy, and results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2005

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals with Barrett's esophagus or adenocarcenoma of the esophagus whose medical care is at the participating institutions, are referred from outside institutions, or who contact the participating institutions.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Eligible cases will be defined as those patients and their family members who meet the following criteria: * Barrett's esophagus confirmed by review of pathology and endoscopy report or adenocarcinoma of the esophagus or family members of person with Barrett's esophagus or adenocarcinoma of the esophagus. * Male or female age 18 or older at time of enrollment or male or female less than 18 years of age at time of enrollment with parental consent. * Ability to give informed consent, if patient is age 18 or older.

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Conditions

The condition(s) this trial relates to.

Barrett esophagus esophageal adenocarcinoma Esophageal Neoplasms neoplasm of esophagus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Barrett's esophagus Esophageal neoplasm

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    10 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Columbia University Medical Center

    RECRUITING

    New York, New York, 10032, United States

  • Fred Hutchinson Cancer Research Center, UWMC

    RECRUITING

    Seattle, Washington, 98109, United States

  • Johns Hopkins Hospital

    RECRUITING

    Baltimore, Maryland, 21205, United States

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • University Hospitals of Cleveland

    RECRUITING

    Cleveland, Ohio, 44106-8066, United States

  • University of North Carolina at Chapel Hill

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

  • University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • VA Puget Sound Health Care System

    RECRUITING

    Seattle, Washington, 98108, United States

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.