Diabetic foot ulcer (DFU)

This trial tests whether a collagen-based skin substitute can heal diabetic foot ulcers better than a fish skin matrix. Adults with diabetes and a non-healing foot ulcer will receive either treatment along with standard wound care. The main goal is to see which approach leads to …

This trial is testing whether an investigational wound gel called VES-0-D can help heal mild-to-moderate diabetic foot ulcers better than standard wound care. Adults with type 1 or type 2 diabetes and a foot ulcer will receive either the gel or a standard dressing, applied every …

This pilot study tests a program called CARE-D-Foot-Nav, where a trained navigator, such as a diabetes educator, helps people with diabetic foot ulcers access specialized care. Participants receive weekly check-ins by phone or in person for 20 weeks, plus practical help like tran…

This early-stage study tests a new treatment called VELGRAFT, made from living cells, for people with diabetic foot ulcers that have started to form new tissue but haven't healed. About 24 adults with type 1 or type 2 diabetes will receive either VELGRAFT plus standard care or st…

This trial is testing whether a new biological treatment called CYWC628, made from human skin cells, can help heal diabetic foot ulcers that have not responded to standard care. Adults with type 1 or 2 diabetes and a foot ulcer will receive either standard care alone or standard …

This phase 2 trial investigates whether oral L-carnitine, a natural compound, can improve wound healing in people with diabetic foot ulcers. Researchers will measure changes in ulcer size and depth over 12 weeks, along with markers like VEGF, inflammation, and blood sugar control…

This trial tests whether a coordinated team of hospital and community healthcare professionals can improve healing of hard-to-heal ulcers compared to standard care. Adults with such ulcers are randomly assigned to either the multidisciplinary team or usual treatment. The main goa…

This trial investigates whether two special wound dressings—one made from donated amniotic membrane and another from a synthetic material—can help heal diabetic foot ulcers and venous leg ulcers that have not responded to standard care. Adults aged 18 and older with these hard-to…

This study tests whether a special placental graft, used alongside standard wound care, helps close diabetic foot ulcers that won't heal on their own. About 350 adults with type 1 or 2 diabetes and a foot ulcer between 1 and 15 cm² will be randomly assigned to get the graft plus …

This study tests a new hydrogel made with plasma-activated water on chronic wounds like diabetic foot ulcers and pressure sores. Fifty adults will either get the gel or standard wound care for 12 weeks. Researchers will check if the gel helps wounds close faster and lowers bacter…

This study tests a gel called Chlorin E6 that is activated by light to treat diabetic foot ulcers. About 300 adults with diabetes and foot sores that have lasted at least 4 weeks will receive either the gel plus standard care or standard care alone. The goal is to see if the trea…

This study tests whether a weekly application of Xcell Amnio Matrix, a processed amniotic membrane, can help heal diabetic foot ulcers better than standard care alone. About 135 adults with diabetes and a foot ulcer that hasn't healed in 4 weeks to 1 year will take part. The main…

This study tests whether adding a placental-based skin substitute to standard wound care helps close hard-to-heal diabetic foot ulcers faster than standard care alone. About 272 adults with diabetes and a foot ulcer present for 4 to 52 weeks will receive either the skin substitut…

This study tests a special wound covering made from donated placental tissue, called DermaBind TL, in 150 adults with diabetic foot or venous leg ulcers that won't heal. The goal is to see if the graft safely helps shrink or close the wound over 13 weeks. Participants must be 18-…

This study tests whether a special tri-layer amnion graft or a single-layer amnion graft can help heal diabetic foot ulcers and venous leg ulcers that have not improved with standard care. About 165 adults with wounds between 2 and 25 cm² that have been open for over 4 weeks will…

This study tests whether adding a special patch called Amnio-Maxx to usual wound care helps close chronic diabetic foot ulcers faster than usual care alone. About 248 adults with diabetes and a nonhealing foot ulcer will take part. The main goal is to see if the patch leads to co…