Diabetic foot ulcer

Researchers are testing whether seltoplasmid, a gene therapy injected into the calf muscle, can improve outcomes for people with type 2 diabetes who have poor blood flow to the foot and a non-healing ulcer. All participants first undergo a standard procedure to restore blood flow…

This trial tests whether adding a modified herbal decoction, called Simiao Yongan, to standard care helps heal diabetic foot ulcers and prevent major amputations. The study enrolls 120 people with diabetic foot ulcers who have already had a procedure to restore blood flow to the …

This trial tests whether injecting a person's own fat tissue, processed with the SyntrFuge system, can help diabetic foot ulcers heal faster. About 62 people with diabetic foot ulcers will be randomly assigned to receive either the fat graft or standard wound care. The main goal …

This early-stage trial is testing whether injecting placental stem cells into and around non-healing diabetic foot ulcers is safe. The study involves 12 people with Type 2 diabetes who have a foot ulcer that has not healed for at least four weeks despite standard care. Researcher…

This pilot study tests whether injecting dexpanthenol (a vitamin B5 derivative) under the skin around chronic wounds can help them heal faster. 40 adults with diabetic foot ulcers, venous leg ulcers, or arterial ulcers will receive either standard wound care alone or standard car…

This study tests whether adding cold atmospheric plasma (CAP) to standard wound care helps diabetic foot and venous leg ulcers heal faster and stay healed longer. About 494 adults with these chronic wounds will receive either standard care alone or standard care plus CAP. The goa…

This study tests a special foot care program (DiaFOOTCare) for people with type 2 diabetes who are at risk of developing foot ulcers. About 78 participants will be split into two groups: one receives the program, the other gets standard care. The goal is to see if the program imp…

This trial is testing a soft silicone foam dressing called Mepilex Up on adults with leg or foot ulcers and skin tears. The goal is to see if the dressing helps wounds progress toward healing and is safe to use. About 70 participants will use the dressing for up to 6 weeks, and d…

This study will test if a type of light therapy called monochromatic infrared energy (MIRE) can help heal diabetic foot ulcers. About 40 adults with diabetes and a chronic foot sore will receive MIRE treatment. Researchers will track wound size and quality of life to see if the l…

This study tests whether a 12-week exercise program can safely improve mobility in people aged 50 and older who have recently healed from a diabetic foot ulcer. Participants will either do seated cycling and strength exercises or follow standard care guidance. The goal is to see …

Researchers are testing whether standard blood tests can indicate the quality of stem cells taken from the heel bone during foot or ankle surgery. The study includes adults aged 40 to 80, some with type 2 diabetes and diabetic foot ulcers. Before surgery, participants give blood …