DERMATOMYOSITIS

This study is testing the safety of the immunotherapy drug nivolumab in people who have both advanced cancer and an autoimmune disease like lupus, rheumatoid arthritis, or Crohn's disease. It will enroll 300 adults to see how well they tolerate the treatment and to find the right…

This early-stage trial is testing whether modified immune cells called CAR-T cells can help control severe autoimmune diseases like lupus, scleroderma, and muscle inflammation diseases. The treatment involves collecting a patient's own immune cells, genetically modifying them to …

This study is testing whether a topical cream called ruxolitinib is safe and effective for treating severe skin symptoms in adults with dermatomyositis, an autoimmune disease. The cream is being studied in 15 participants whose skin symptoms have not improved with other standard …

This study is testing a one-time cell therapy called CABA-201 for adults and children with rare autoimmune diseases that cause severe muscle weakness and inflammation. The goal is to see if this treatment can safely reduce disease activity and improve muscle strength, potentially…

This study is testing whether the drug tocilizumab can help control symptoms and lung problems in adults with a specific, serious form of dermatomyositis (anti-MDA5+). Researchers will compare the drug to a placebo (inactive substance) in 110 participants to see if it improves sk…

This study aims to understand the long-term safety and effectiveness of the drug dazukibart for adults with dermatomyositis or polymyositis, two rare diseases that cause painful muscle weakness and inflammation. The trial is open to people who previously completed a related 52-we…

This early-stage study is testing a new drug called SAR448501 in adults with moderate-to-severe lupus or rheumatoid arthritis who haven't gotten enough relief from their current treatments. The main goal is to find safe dose levels and see how the drug behaves in the body. About …

This study is testing whether injecting a medication called sodium thiosulfate directly into painful calcium deposits under the skin can shrink them and reduce pain. It will involve about 20 adults with connective tissue diseases like scleroderma or dermatomyositis who have these…

This study aims to understand why dermatomyositis, a rare autoimmune disease affecting skin and muscles, appears to be more severe in Caribbean populations. Researchers will observe 10 patients in Guadeloupe to identify factors linked to worse outcomes. The study involves observa…

This study aims to understand whether certain environmental exposures—like infections, chemicals, or stressful events—might trigger autoimmune muscle diseases called myositis. Researchers will compare 580 people with myositis to healthy volunteers, collecting blood, dust samples,…

This study aims to understand what research matters most to people living with rare muscle diseases called myositis. Researchers will collect perspectives from 700 patients and caregivers worldwide through online surveys and discussions. The goal is to create a list of patient-pr…

This study is creating a database to track how skin symptoms change over time in adults with dermatomyositis, a rare autoimmune disease that causes muscle weakness and skin rashes. Researchers at the University of Pennsylvania will follow 300 patients for 5 years, collecting info…

This study is creating a large collection of health information and biological samples from people with various rheumatic diseases like rheumatoid arthritis and lupus. The goal is to help researchers better understand what causes these conditions and how they progress over time. …

This study aims to better understand the causes and effects of rare inflammatory muscle diseases like dermatomyositis and polymyositis. Researchers will observe up to 1,200 participants, including both patients and healthy volunteers, over time. The goal is to learn how these dis…

This study is tracking the long-term safety and effects of an experimental cell therapy called KYV-101 in people who have already received it. Researchers will follow 70 participants for up to 15 years to check for any delayed side effects and see how long the treatment's effects…

This study aims to better understand a rare skin condition called panniculitis in people who have dermatomyositis, a muscle and skin disease. Researchers will observe up to 20 patients to describe how this condition looks on the skin and under a microscope. The goal is to gather …