DERMATOMYOSITIS

This study tests a new treatment using specially engineered immune cells (CAR-T cells) to target and destroy faulty B cells in people with severe autoimmune diseases like lupus, rheumatoid arthritis, and scleroderma. About 72 adults will receive the cells in increasing doses to f…

This study tests a new treatment for people with lupus, scleroderma, or certain muscle diseases. The treatment uses a patient's own immune cells, modified to find and attack faulty B cells that drive the disease. About 24 adults will receive the therapy after a short course of ch…

This study tests whether tocilizumab, a drug used for arthritis, can improve symptoms and breathing in adults with a rare form of dermatomyositis (anti-MDA5+). About 110 participants will receive either the drug or a placebo every two weeks for two months. The goal is to see if i…

This study looks at the long-term safety of a medicine called dazukibart for people with dermatomyositis or polymyositis, which are rare diseases that cause muscle weakness and can affect daily activities. About 211 adults who completed a previous dazukibart study will receive th…

This early-stage study tests a new medicine, SAR448501/DR-0201, in adults with lupus or rheumatoid arthritis. The goal is to find safe and tolerable doses by checking side effects and how the drug works in the body. About 62 participants will receive multiple doses and be followe…

This study tests a new treatment called CABA-201 for people with active inflammatory myopathy, a group of rare diseases where the immune system attacks muscles. The treatment uses a patient's own immune cells, modified to target and destroy certain immune cells that cause the dis…

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This study tests whether injecting sodium thiosulfate directly into painful calcium deposits can shrink them and ease symptoms. It includes 20 adults with scleroderma, dermatomyositis, or mixed connective tissue disease who have calcium buildup in skin or tendons. Participants re…

This study tests a cream called ruxolitinib for treating stubborn skin rashes in people with dermatomyositis, a rare autoimmune disease. Researchers want to see if the cream is safe and can reduce skin activity and severity over 8 to 12 weeks. The study involves 15 adults and is …

This study aims to learn more about myositis, a group of diseases that cause muscle inflammation and damage. Researchers will observe up to 1,200 adults and children with myositis, along with healthy volunteers, to track symptoms, immune system changes, and related health issues.…

This study gathers information from 300 adults with dermatomyositis to learn more about the disease, how it changes over time, and how treatments affect symptoms and quality of life. Participants complete surveys and skin assessments, but no new treatments are tested. The goal is…

This study looks at how severe dermatomyositis is in people from the Caribbean, especially in Guadeloupe. Researchers will track 10 patients to see how often the disease affects muscles, organs like the lungs and heart, or is linked to cancer. The goal is to learn more about the …

This study is building a large collection of health information and blood samples from 5,000 adults with rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers will use this data to find links between patient outcomes and biological markers. The goal is…

This study asks people with rare myositis diseases (like dermatomyositis or inclusion body myositis) and their caregivers what they think researchers should focus on. Through online surveys and forums, the goal is to create a list of patient-driven research priorities. The study …

This study looks at a rare condition called panniculitis (inflammation of the fat under the skin) in people with dermatomyositis. Researchers want to describe how it looks and behaves, both on the skin and under a microscope, to tell it apart from similar conditions. The study wi…

This study looks at whether certain environmental exposures—like infections, stress, or sun exposure—are more common in people with anti-synthetase syndrome (a type of myositis with lung involvement) compared to other myositis patients and healthy volunteers. Researchers will col…

This study tracks 70 people who have already received an infusion of KYV-101, a CAR T cell therapy, for autoimmune diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal is to watch for delayed side effects, new cancers, or other health problems over up to 15…