CYSTIC FIBROSIS

This study tests whether losartan, a blood pressure medication, can help clear mucus from the lungs of people with cystic fibrosis (CF) who cannot take current CFTR-targeted therapies. Sixteen adults with mild to moderate lung disease will take losartan for over 12 weeks. The goa…

This study follows 70 infants with cystic fibrosis to see if a bacteria called Porphyromonas catoniae, measured at 12 months old, can predict if they will get a Pseudomonas aeruginosa lung infection by age 3. Researchers collect sputum and stool samples over time. The goal is to …

This study follows 285 pregnant women with cystic fibrosis to see how their lung function changes during and after pregnancy while using CFTR modulators. Researchers measure breathing capacity before, during, and up to two years after delivery. The goal is to better understand th…

This study aims to understand how cystic fibrosis (CF) damages small blood vessels in the lungs. Researchers will use imaging to measure blood vessel changes in 86 people with CF, ages 5 to 21, and compare them to lung function. The goal is to learn more about the disease, not to…

This study looks at how different genes can change the severity of lung disease in people with cystic fibrosis. Researchers will study 600 people with CF to find genetic clues. No treatment is given—this is an observation-only study.