CRC (COLORECTAL CANCER)

This early-stage study tests a new drug, ADU-1805, in people with advanced solid tumors that have not responded to standard treatments. The drug is given alone or with another cancer drug (pembrolizumab). The main goals are to check safety and how the body processes the drug. Abo…

This early-phase study tests a new drug called ALX2004 in people with advanced lung, head and neck, colorectal, or esophageal cancers that have stopped responding to standard treatments. ALX2004 is an antibody-drug conjugate designed to deliver a toxic payload directly to cancer …

This early-phase study tests a new drug called KQB365 in adults with advanced solid tumors that have KRAS G12S or G12C mutations and no standard treatment options. The main goals are to find a safe dose and see if KQB365 alone or combined with other drugs (cetuximab or KQB198) ca…

This study tests whether adding the drug SHR-1701 to standard chemoradiotherapy can completely eliminate advanced rectal cancer before surgery. About 48 adults with severe rectal cancer will receive the drug combination, then undergo surgery to remove any remaining tumor. The mai…

This early-stage study tests a new drug called TGI-5, alone or with another drug (nivolumab), in people with advanced solid tumors like colorectal, liver, melanoma, and lung cancer. The main goals are to check safety and find the right dose. About 194 adults will take part. This …

This early-stage trial tests a new drug called ALTA3263 in adults with advanced solid tumors (like pancreatic, lung, or colorectal cancer) that have a KRAS mutation. The main goals are to check safety and find the right dose. About 188 people whose cancer has worsened after stand…

This study tests a new drug (GFH375) combined with either cetuximab or chemotherapy in people with advanced solid tumors that have a specific KRAS G12D mutation. The goal is to see if the combination is safe and can shrink tumors. About 126 adults who have not responded to standa…

This early-phase study tests a new drug called BBO-11818 in people with advanced solid tumors (lung, pancreatic, colorectal, or others) that have a specific KRAS gene mutation. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. Abo…

This study tests whether adding the experimental drug INCA33890 to standard chemotherapy and bevacizumab helps people with metastatic colorectal cancer live longer without their disease getting worse. About 700 adults with a specific type of colorectal cancer (MSS) that has sprea…

This early-stage trial tests a new method called PIPAC that sprays chemotherapy directly into the abdomen for people with colorectal cancer that has spread there. The study aims to find the safest dose and check for side effects. About 42 adults aged 18-75 with no other cancer sp…

This study tests a real-time AI system that helps doctors measure the size of polyps found during colonoscopy. Accurate size is key because polyps larger than 10 mm have a higher risk of turning into cancer. About 278 adults getting a colonoscopy will join, and the AI's measureme…

This study tests a new way to create detailed 3D images of lung and colorectal cancer tissue. Researchers will use a special preprocessing system and staining technique to get clearer pictures than standard 2D methods. The goal is to help doctors diagnose cancer more accurately a…

This study tests an experimental drug called NGM120 in 136 people with colorectal cancer who are experiencing cancer-related weight loss (cachexia). The goal is to see if the drug helps patients gain or maintain weight and is safe to use. Participants will receive either NGM120 o…

This study aims to develop a blood test that can tell doctors which patients with advanced colorectal cancer will respond well to certain targeted therapies. Researchers will analyze DNA fragments in the blood of 500 patients to find patterns linked to treatment success or failur…

This study aims to find out if a simple blood test can predict which patients with metastatic colorectal cancer will respond well to standard chemotherapy. Researchers will analyze blood samples from 600 patients before they start treatment. The goal is to develop a test that hel…

This study looks for new substances in the blood that could signal colorectal cancer or precancerous growths. Researchers will compare blood samples from people with colorectal cancer, people with precancerous polyps, and healthy individuals. The goal is to create a scoring syste…

This study looks at whether a video featuring a virtual tribal community health educator can help more American Indians aged 45-75 get screened for colorectal cancer. About 150 participants in Oklahoma will either watch a real-life testimonial or interact with the virtual educato…