CRC (COLORECTAL CANCER)

This early-stage trial is testing a new drug called BBO-11818 in people with advanced cancers that have specific KRAS gene mutations. The study aims to find a safe dose and see if the drug can shrink tumors in cancers like lung, pancreatic, and colorectal cancer. Participants wil…

This is a first-in-human study to find a safe dose and see how well a new drug called TGI-5 works, both by itself and combined with an existing immunotherapy (nivolumab). It is for adults with advanced solid tumors (like lung, colon, skin, or liver cancer) that have spread and no…

This is the first study in people to test a new experimental cancer drug called ALX2004. It aims to find a safe dose and see if the drug can help control advanced cancers that have spread and stopped responding to other treatments. The trial will enroll about 170 adults with spec…

This early-stage study is testing a new way to deliver chemotherapy directly into the abdomen for people with colorectal cancer that has spread there. Doctors spray the chemo as a pressurized mist during a minimally invasive procedure, hoping it will better target the cancer. The…

This study is testing whether adding the experimental drug SHR-1701 to standard chemotherapy and radiation before surgery helps treat locally advanced rectal cancer. The goal is to shrink tumors as much as possible to improve surgical outcomes. About 48 adults with advanced recta…

This early-stage trial is testing a new immune therapy drug called ADU-1805, both alone and combined with an existing cancer drug (pembrolizumab). It aims to find safe doses and see if the treatment helps control advanced solid tumors that haven't responded to standard treatments…

This early-stage study is testing a new type of CAR-T cell therapy for people with metastatic colorectal cancer that has not responded to standard treatments. Instead of using the patient's own cells, this 'universal' therapy uses modified immune cells from healthy donors. The ma…

This study is testing whether combining the experimental drug GFH375 with either cetuximab or chemotherapy can help control advanced solid tumors that have a specific KRAS G12D mutation. The trial will enroll 126 adults whose cancers have progressed despite standard treatments. R…

This large, late-stage study is testing whether adding a new experimental drug called INCA33890 to standard chemotherapy can better control advanced colorectal cancer that has spread. It will involve 700 people with a specific type of cancer (microsatellite stable) who have not y…

This early-stage trial is testing a new oral medication called ALTA3263 in adults with advanced solid tumors that have specific KRAS mutations. The study aims to find a safe dose and see how the body processes the drug, while also checking for early signs that it might help contr…

This study is testing a new way to create detailed 3D pictures of lung and colon cancer tumors from patient tissue samples. Researchers will use a special process to make the tissue clear and then stain it with fluorescent dyes to see its full 3D structure. The goal is to help do…

This study is testing whether a virtual health coach can encourage more American Indians in Oklahoma to get screened for colorectal cancer. Researchers will recruit 150 people who are not up to date with their screening. They will compare if people are more likely to order a home…

This study aims to develop a simple blood test that can predict whether a patient's advanced colon cancer will respond to standard chemotherapy. Researchers will analyze chemical markers in DNA from the blood of 600 patients who have already received treatment. The goal is to cre…

This study aims to develop a blood test that can predict which patients with advanced colorectal cancer will respond to specific targeted therapies. Researchers will analyze DNA fragments in the blood of 500 patients to find patterns linked to treatment success. The goal is to cr…

This study aims to find new, non-invasive signs in the blood that could help detect or predict colorectal cancer. Researchers will collect blood and tissue samples from 60 people across three groups: those with colon cancer, those with a pre-cancerous condition, and healthy indiv…