CORONARY DISEASE

This study tests a health behavior program for 200 people with coronary heart disease. The program includes exercise support and remote monitoring to improve walking ability, reduce frailty, and boost quality of life. It is not a cure but aims to help patients manage their condit…

This study compares two drug-coated stents (SUPRAFLEX Cruz and SYNERGY) in about 1,550 people with severe blockages in three heart arteries. Participants receive modern heart care including imaging and medications. The goal is to see which stent is safer and more effective at pre…

This study compares two imaging techniques, OCT and IVUS, to better evaluate blockages in the left main coronary artery. Researchers will enroll 153 adults with intermediate blockages to see which method provides clearer guidance for treatment. The goal is to improve accuracy and…

This study is gathering information from over 130,000 people who have had a heart attack or unstable chest pain. Researchers will look at treatments, outcomes, and genetic data to learn what works best. The goal is to help doctors and policymakers make better decisions for heart …

This study follows over 5,000 Black and White adults from age 18-30 for decades to see how their lifestyle and health changes affect heart disease risk later in life. Researchers measure things like blood pressure, weight, and cholesterol over time. The goal is to understand what…

This long-term study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related disabilities. Researchers used medical records and exams to identify risks and triggers. The goal was to better understand how to prevent these con…

This study looks at 500 women with chest pain to compare two common heart tests (FFR and iFR) used during catheterization. The goal is to see which test better predicts future heart problems like heart attacks or strokes over 5 years. Participants will have standard care and be f…

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older already on a keto diet or starting the modified Atkins diet.…

This long-term study followed over 6,400 adults from different racial and ethnic backgrounds to learn how early signs of heart disease develop and lead to serious events like heart attacks or strokes. Participants were healthy at the start and were monitored for years through exa…

This study follows over 5,000 people with stable heart disease for up to 10 years to compare two treatment approaches: an early invasive strategy (procedures like stents or bypass) plus medications, versus medications alone. Researchers want to see if one strategy leads to fewer …

This study follows 2,314 South Asian adults (ages 40-84) in the US to uncover why they have high rates of heart disease and stroke, even without typical risk factors. Researchers measure artery calcium, diabetes, and other markers over time. The goal is to identify unique causes …

This study watches 2,000 people with coronary artery disease who received the Xience Sierra stent during routine care. Researchers track deaths, heart attacks, and repeat procedures to see how safe and effective the stent is compared to other stents. The goal is to learn how the …

This study tests whether giving doctors a special risk score—one that combines a person's genes with things like cholesterol and age—helps them make better decisions to prevent heart disease. About 1,000 people at moderate risk for heart disease but who have never had a heart att…

This study follows over 6,000 people over many years to see if traits like hostility and other emotional factors are linked to heart disease. Researchers are observing participants without giving any treatment. The goal is to better understand what leads to heart problems, not to…

This study looks at whether getting an angiogram (a special X-ray of the heart arteries) 6 months after a stent procedure in the left main coronary artery can lower the risk of death, heart attack, or stroke over the next 3 years. About 400 adults aged 18-85 who received a specif…