COPD (CHRONIC OBSTRUCTIVE PULMONARY DISEASE)

This study looks at whether using a heart-lung machine (ECMO) routinely during lung transplants is better than using it only when necessary. About 218 people getting a lung transplant will take part. The goal is to find out which approach reduces time in the ICU and improves reco…

This study tests a program called PEACE, where specially trained paramedics visit people with COPD at home when their symptoms suddenly worsen. The goal is to provide early care and avoid trips to the emergency room. About 50 adults with moderate to severe COPD will take part, an…

This study tests a new daily pill, JKN2403, in 120 adults with moderate-to-severe COPD. The goal is to see if it reduces serious flare-ups and improves breathing and quality of life compared to a placebo. Participants take the pill or placebo for 24 weeks and visit the clinic mon…

This study looks at whether finding and treating COPD early can help people who are also being checked for lung cancer. About 280 adults with breathing problems will get either standard care or extra COPD treatment. The goal is to see if this improves symptoms, quality of life, a…

This study follows about 400 adults with severe COPD in Brazil who are already using the Trimbow® inhaler. Researchers will track their symptoms and lung function over 6 months to see how well the medication controls the disease in everyday practice. The goal is to understand rea…

This study tests whether a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) is better than a dual inhaler at preventing serious heart and lung events in people with COPD. About 5,000 adults aged 40–80 who smoke or used to smoke will take part. The goal is t…

This study looks at whether adding probiotics to standard pulmonary rehabilitation can improve inflammation and overall health in people with COPD. About 60 adults with COPD will take probiotics alongside their rehab program. Researchers will measure things like breathing, body c…

This study looks at whether having a heart doctor check patients during a COPD flare-up can find and treat hidden heart problems. 150 adults hospitalized for COPD will be split into two groups: one gets standard lung care, the other also sees a heart doctor. Both groups are follo…

This study tests whether eating more omega-3s (found in fish and certain oils) can improve breathing and quality of life for people with COPD. Two hundred adults with moderate to severe COPD will receive either a special diet or their usual meals. Researchers will track changes i…

This study tests a 10-week community-based pulmonary rehabilitation program (COPD Wellness) combined with social navigation (Health Advocates) to help vulnerable COPD patients improve their walking ability and quality of life. About 387 adults aged 40-90 with confirmed COPD who s…

This study tests whether a 3-month supervised maintenance program, including exercise and education sessions, can help people with COPD maintain improvements in breathing and quality of life after an initial 8-week pulmonary rehab program. About 86 adults aged 40-75 with moderate…

This study tests a new ventilator (INBENTUS VERSATILE) in 81 adults who need help breathing due to conditions like pneumonia, ARDS, or COPD. Participants will use the ventilator for 3 to 48 hours, and researchers will monitor for side effects and how well the machine works. The g…

This study is testing a computer tool that uses health records to predict if someone has COPD, a serious lung disease. Many people with COPD are not diagnosed until the disease is advanced, while others are wrongly told they have it. The goal is to see if the tool can correctly i…

This study tests a device that uses short electric pulses to treat chronic bronchitis symptoms in adults with COPD. About 210 people will be randomly assigned to receive the real treatment or a sham procedure. The goal is to see if the device safely reduces coughing and mucus, im…

This study looks at whether combining posture correction exercises with special breathing training can help people with COPD who also have a forward head posture. Researchers will compare three types of breathing training over 8 weeks in 72 adults aged 40-60. The goal is to see i…

This study tests whether an inhaled medication called Treprostinil (Tyvaso) can help deliver more oxygen to the blood in people with COPD who have low oxygen levels. Ten adults aged 40 and older will use a nebulizer four times daily for four weeks. Researchers will use special MR…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce depression and anxiety in adults with COPD, ALS, multiple sclerosis, or atypical Parkinson disease. 108 participants will receive either two moderate-to-high doses or two very low dos…

This study tests a new 3-month counseling program for people with stable COPD. The program is led by a nurse and focuses on emotional distress caused by the disease. It includes 10 sessions and involves other healthcare professionals. The goal is to see if this approach is practi…

This study tests whether a special support program can improve quality of life for people with advanced COPD. The program includes a full needs check, planning future care, and meetings between hospital and community teams. About 100 adults with COPD who had a flare-up in the las…

This study tests whether eating freeze-dried aronia berries daily can lower inflammation and improve breathing in people with COPD. Fifty adults aged 50 to 80 will take either aronia powder or a placebo for 8 weeks. Researchers will measure blood markers of inflammation and lung …

This study looks at whether a respiratory rehabilitation program (exercise and breathing training) can improve sleep quality in people with stable COPD. About 90 adults aged 50 and older with COPD will be randomly assigned to either the rehab program or their usual care. The main…

This study explores whether doing lung rehabilitation exercises in underground salt chambers can improve breathing and quality of life for people with COPD. 80 adults with stable COPD will be randomly assigned to one of four groups: rehab in a salt chamber, rehab in a regular gym…

This study tests a computer program (Viz COPD) that alerts doctors when a COPD patient needs a follow-up appointment after an emergency visit. About 485 adults with COPD will take part. The goal is to see if the tool helps more patients see a lung specialist within 30 days, compa…

This study looks at how the common cold virus (rhinovirus) causes serious breathing problems in people with COPD. Researchers will intentionally infect 50 volunteers (some with COPD, some healthy) with the virus in a controlled setting. They will take samples from the lungs and b…

This study surveys 250 adults with COPD to learn about their attitudes toward traditional and complementary medicine (like herbal treatments, acupuncture, and cupping). Researchers want to understand which methods patients use, how often, and why. The goal is to gather informatio…

This study follows 693 adults in Brazil with severe or very severe COPD to track how often they are hospitalized, have flare-ups, or die. Researchers want to understand the real-world impact of the disease because there is no national data on this group. Participants will be obse…

This study looks at whether CT scans done for lung cancer screening can also help find COPD, a lung disease, in current and former smokers aged 50-80. About 200 participants will have their scans checked and may take a breathing test. The goal is to learn how to spot COPD earlier…

This study is testing a new type of CT scanner (photon-counting CT) to see if it can measure lung damage from COPD more accurately than current scanners. About 40 adults from an existing COPD study will get an extra scan. The goal is to improve how doctors track emphysema and air…

This study measures three blood markers (GDF-15, MR proADM, and Presepsin) in 60 men under 65 who have acute coronary syndrome, pneumonia, and COPD, and have received an influenza vaccine. The goal is to see if these markers relate to the patients' health and how the vaccine affe…

This study looks at how often heart failure with preserved ejection fraction (HFpEF) occurs in people with chronic obstructive pulmonary disease (COPD). Researchers will follow 200 hospitalized COPD patients aged 50 to 70 to track their health, including deaths, hospital readmiss…

This study looks at 25 people with COPD and high carbon dioxide levels who need a breathing mask (non-invasive ventilation) to help them breathe. Researchers want to see if nighttime breathing problems can predict how well the treatment works over 6 to 12 months. They will also c…

This study tests a French version of a questionnaire that measures the burden on people caring for a loved one with COPD. Researchers will ask 224 caregivers to fill out the questionnaire and compare it with other standard surveys. The goal is to provide a reliable tool to identi…

This study looks at people with COPD who use a home breathing machine (NIV). Researchers will use artificial intelligence to analyze breathing data already collected by the machine, such as airflow and pressure. The goal is to find early signs that a COPD flare-up may be coming. …