COPD (chronic obstructive pulmonary disease)

Researchers are testing REGEND001, a therapy made from a patient's own airway basal stem cells, to see if it can improve lung function in people with chronic obstructive pulmonary disease (COPD) and emphysema. The trial enrolls adults aged 40 to 75 with moderate to severe COPD. P…

This study tests whether mepolizumab, an injectable medication, can improve lung ventilation and reduce mucus plugs in adults with COPD who have elevated eosinophils. Participants receive mepolizumab every 4 weeks for 48 weeks and undergo MRI and CT scans along with breathing tes…

This trial tests whether active remote management—where a respiratory therapist regularly reviews ventilator data and adjusts settings—can improve quality of life and reduce flare-ups in COPD patients with chronic hypercapnia using home breathing support. Participants are randoml…

This study tests whether a 12-week tele-pulmonary rehabilitation program, done at home via an app with a physiotherapist, helps people with chronic lung diseases start and stick with rehab better than going to a center. 90 patients will be randomly assigned to either remote rehab…

This phase 3 study tests whether an inhaled medication called HSK39004 can improve lung function in people with moderate to severe chronic obstructive pulmonary disease (COPD). Participants receive either the drug or a placebo twice daily for 24 weeks. The main goal is to measure…

This study tests the long-term safety and effectiveness of an experimental inhaler called HSK39004 in 300 adults aged 40 to 80 with moderate-to-severe COPD. Participants will use the inhaler twice daily for 52 weeks. The main goal is to monitor side effects and see how well the t…

This study tests a device that targets nerves in the lungs to help people with moderate to severe COPD breathe easier. About 300 participants will be randomly assigned to receive the real treatment or a sham procedure. Researchers will track symptoms, exercise ability, and flare-…

This study tests whether adding a thorough heart evaluation to standard lung care helps people with mild-to-moderate COPD who also have heart risks. About 350 adults will be randomly assigned to either the combined heart-lung check or usual respiratory care. The goal is to see if…

This early-stage trial tests an oral probiotic called R-3750 in 27 people with mild-to-moderate COPD. The main goal is to see if it is safe and tolerable. Researchers will also check if it improves breathing and quality of life using a standard questionnaire. The study is not yet…

This Phase 2a trial tests whether Hemay005 can reduce lung inflammation in people with moderate to severe COPD. About 120 adults will take Hemay005, the existing drug roflumilast, or a placebo for 12 weeks. Researchers will measure changes in sputum and blood markers to see if He…

This study tests whether using a BiPAP breathing machine at home can help people with severe COPD who have high carbon dioxide levels. Forty adults will use the machine nightly for a year while continuing standard medications. Researchers will track blood gas levels, breathing sy…

This study tests whether newer breathing technologies, such as capnography and oscillometry, can diagnose COPD as accurately as the standard spirometry test. Spirometry requires forceful blowing, which can be uncomfortable. Researchers will compare these tests in 300 adults with …

This study is testing a new, easy way to diagnose asthma and COPD using a handheld device that measures carbon dioxide in a person's breath. Instead of the current uncomfortable and time-consuming lung tests, participants simply breathe normally into the device for 75 seconds. Th…

RESP-FIT tests whether a home-based breathing muscle training program, paired with a mobile app for symptom tracking and activity monitoring, can improve breathlessness, breathing strength, and physical activity in adults with COPD. Researchers are enrolling 288 adults aged 40 an…

Researchers are testing whether a structured breathing program called Active Cycle of Breathing Techniques, combined with a handheld positive expiratory pressure device, can improve breathing, sleep, and mood in people with COPD. The trial enrolls 60 adults aged 40 to 90 with dia…

This trial tests whether two simple breathing exercises—alternate nostril breathing and bellows breath—can help people with COPD clear mucus from their lungs, improve lung function, and feel better day-to-day. About 54 participants will practice one of the techniques for 15–20 mi…

This study compares two airway clearance methods—autogenic drainage (a controlled breathing technique) and a flutter device (a handheld tool that vibrates to loosen mucus)—in people with moderate COPD. Over six weeks, researchers will measure changes in shortness of breath, lung …

This study tests whether a wearable hip exoskeleton can reduce breathlessness and improve walking efficiency in people with moderate to severe COPD. Ten participants will walk on a treadmill for 30 minutes with and without the device, while researchers measure breathing, walking …

This study tests a home-based pulmonary rehabilitation program for people with COPD. Participants will follow video-guided exercises, track their daily steps, and receive weekly health coaching. The goal is to improve quality of life, reduce breathlessness, and encourage a more a…

This study tests whether a 12-week remote group rehabilitation program, done via video calls and a smartphone app, can help COPD patients living in remote areas start and stick with rehab. It compares this approach to standard in-person rehab. The goal is to see if the remote opt…

This study tests whether a treadmill workout that combines walking downhill (eccentric) and uphill (concentric) is better than standard uphill walking for people with mild to moderate COPD. Forty participants will do 12 exercise sessions over 4 weeks. Researchers will measure leg…

This study looks at whether a pulmonary rehab program for COPD patients that meets only once a week is as good as one that meets three times a week. About 158 people with COPD will take part, doing supervised exercises plus home workouts for 8 weeks. The goal is to make rehab eas…

This study tests whether it is safe to repeat a procedure called metered cryospray in people with COPD and chronic bronchitis who have already had it once. Only 10 participants will be enrolled. The main goal is to see if the treatment can be fully delivered and to track any seri…

This study looks at whether manual therapy (a type of hands-on treatment) can improve how people with COPD walk, including their step length and balance. Researchers will also check if it helps with breathing, muscle strength, and quality of life. The study plans to enroll 40 adu…

This study tests a digital breathing trainer that helps COPD patients strengthen their breathing muscles through forceful inhales and exhales. Sixty participants with moderate to severe COPD will use the device twice daily for eight weeks, alongside standard rehab. Researchers wi…

This study tests if a gentle, non-invasive brain stimulation method can improve memory and attention in people with COPD who have thinking problems. Twenty-four adults with stable COPD and mild cognitive issues will receive either real or fake stimulation for 20 minutes a day, 5 …

Researchers are testing whether a new inhaled version of glycopyrrolate, called AERO-002, delivers the drug to the lungs with less of it entering the bloodstream compared to a standard inhaled glycopyrrolate product. The study enrolls healthy adults aged 18 to 55 who will receive…

Researchers at Hacettepe University are comparing muscle oxygen levels in people hospitalized with a COPD flare-up versus those with stable COPD. They use a light-based sensor to measure oxygen in breathing and limb muscles during simple tasks like standing up and walking. The go…

This pilot study follows 15 adults with COPD who recently left the hospital after a flare-up. Researchers place sensors in their homes to measure air quality, light, noise, and temperature, while participants wear a smartwatch that tracks health data. For one month, participants …

This study aims to create a large collection of lung and airway tissue samples from people with COPD, asthma, and healthy volunteers. Researchers will gather samples through bronchoscopy, sputum, nasal brushing, and blood draws during routine procedures or surgeries. The goal is …

This study compares how COPD patients and healthy individuals experience breathlessness at rest, during exercise, and in virtual reality. Researchers will also test whether a placebo (high-flow nasal cannula) can change how breathlessness feels. The goal is to better understand t…

This study tests a new training program to help nurses teach patients with COPD how to use their inhalers correctly. About 82 registered nurses in Hong Kong will attend a workshop with hands-on practice and follow-up videos. The goal is to see if this training improves nurses' sk…

This study will check how common urinary incontinence is in women with COPD who are doing pulmonary rehabilitation. Researchers will measure leakage with a pad test and ask about quality of life. The goal is to understand the problem better so future treatments can be developed.

This study aims to understand how chronic obstructive pulmonary disease (COPD) affects the quality of life of patients in Nepal. Researchers will ask 71 adults with COPD to complete questionnaires about their symptoms and daily activities. No treatments or medications are tested;…

This study looks at how long-term use of a BiPAP machine affects the diaphragm—the main breathing muscle—in people with advanced COPD. Researchers will use ultrasound to measure diaphragm thickness and movement over 6 weeks and 12 months in 30 patients. The goal is to learn wheth…