CIGARETTE SMOKING

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people switch from smoking cigarettes. Fifty smokers will get either low (3 mg) or high (6 mg) nicotine pouches to use for 4 weeks. Researchers will check if they stop smoking and how much they use the …

This study tests whether changing treatments after an early relapse helps smokers quit. 544 smokers who want to quit will try nicotine patches, lozenges, varenicline, or e-cigarettes. If they slip in the first few weeks, they may switch to a different option. All visits are remot…

This study compares e-cigarettes to standard nicotine replacement therapy (like patches) plus counseling, to see which helps smokers with opioid use disorder cut down on regular cigarettes. About 300 adults in methadone or buprenorphine treatment programs will participate. The go…

This study is for people who smoke cigarettes but aren't ready to quit. It tests whether giving them a choice of harm-reduction products like e-cigarettes or nicotine pouches helps them smoke less or stop altogether. Participants will use their chosen product for 28 days and be f…

This study looks at whether e-cigarettes or nicotine patches and lozenges, combined with counseling and text messages, can help people with serious mental illness reduce their cigarette smoking. 60 participants who smoke at least 5 cigarettes a day will be randomly assigned to on…

This study tests whether a non-invasive brain stimulation technique called rTMS can help people stop smoking. Researchers will use MRI scans to guide the stimulation to brain areas involved in craving and self-control. The trial involves 64 smokers who will receive either real or…

This study is testing a mobile health app designed to help young adults (ages 18–26) quit or reduce their use of e-cigarettes and other vaping products. About 46 participants will use the app and have their progress tracked through interviews and saliva tests. The goal is to see …

This study tests if a once-weekly injection of semaglutide can help adults with overweight or obesity avoid gaining weight after they stop smoking. About 197 participants will receive the drug or a placebo, and researchers will track changes in body weight, body fat, and appetite…

This study looks at how different tax plans affect what smokers choose to buy in a simulated online store. About 316 daily smokers will use a virtual marketplace where cigarettes and other nicotine products have different prices based on tax rules. The goal is to see if certain t…

This study looks at whether the flavor of e-cigarettes affects how likely smokers are to switch from regular cigarettes to e-cigarettes. About 210 smokers who have tried to quit before will be given either fruit, tobacco, or menthol flavored e-cigarettes to use for 6 weeks. Resea…

This study looks at whether e-cigarettes or oral nicotine pouches can help people who smoke cigarettes cut down or switch completely. Two hundred adult smokers who have tried to quit before will be randomly assigned to use one of these products instead of cigarettes for six weeks…

This study looks at how THC, the active part of cannabis, affects cigarette cravings and smoking habits. Researchers will give 100 adults who smoke both tobacco and cannabis different doses of THC or a placebo, then measure how many cigarette puffs they take and how they feel. Th…

This study looks at how setting a very-low-nicotine standard for cigarettes and changing prices of illegal cigarettes and e-cigarettes affects what people buy in a virtual marketplace. About 70 adult smokers and dual users of cigarettes and e-cigarettes will take part. The goal i…

This study looks at how a beta-blocker (propranolol) and nicotine patches affect brain activity and cravings when smokers see smoking-related cues. About 80 daily smokers will take these medications briefly and undergo brain scans. The goal is to understand the brain mechanisms b…

This study aims to understand if relighting a cigarette (smoking it in parts) produces more harmful chemicals than smoking it all at once. Researchers will observe 30 smokers who already relight their cigarettes, measuring their smoking habits and collecting cigarette butts. No t…

This study looks at what happens to markers of inflammation in the blood when menthol cigarette smokers switch to non-menthol cigarettes. The goal is to understand if removing menthol could lower heart disease risk. About 68 adult menthol smokers will be followed for several week…