CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

This study tested a medication called dupilumab, given as an injection, in adults with chronic sinusitis and nasal polyps that were not well-controlled by their usual treatments. Twenty-five Japanese participants received the injection for up to 52 weeks. The main goal was to see…

This study tested whether adding dupilumab injections to a standard nasal spray helps adults in China with chronic sinusitis and nasal polyps. It compared the drug to a placebo in 63 participants over 24 weeks to see if it reduced polyp size and improved symptoms like congestion …

This study tested the long-term safety and effectiveness of an experimental injection called TQC2731 for adults with chronic sinusitis and nasal polyps. It involved 59 participants who had previously been in a related trial. The main goal was to see how safe the treatment was ove…

This study tested whether a low-dose antibiotic (clarithromycin) taken daily for three months could help prevent nasal polyps from growing back after surgery. It involved 100 patients who had surgery for chronic sinusitis with polyps. The group that took the antibiotic had signif…

This study directly compared two existing biologic drugs, dupilumab and omalizumab, to see which works better for adults with severe chronic sinusitis with nasal polyps and asthma. It involved 360 participants who had not gotten enough relief from standard treatments like nasal s…

This large, completed Phase 3 trial tested whether a new injectable medication called tezepelumab could help adults with severe, long-term sinusitis and large nasal polyps. Over 400 participants received either tezepelumab or a placebo shot every four weeks for a year, while cont…

This study monitored the safety and effectiveness of Xolair in adults with chronic sinusitis and nasal polyps who weren't fully helped by standard nasal sprays. It followed 135 Korean patients in their regular doctor's visits for 24 weeks to track any side effects and see if thei…

This study aimed to understand how the medication dupilumab helps people with chronic sinusitis and nasal polyps regain their sense of smell. Researchers followed 60 adults already scheduled to take dupilumab, measuring inflammation and smell ability over three months. The goal w…

Primary objective: to investigate the efficacy of Mepolizumab 100 milligram (mg) every month compared to placebo in reducing validated Sinonasal Outcome Test -22 score and on reducing endoscopic Nasal Polyp Score. The participants have a triad of chronic rhinosinusitis with nasa…