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Common antibiotic shows promise in keeping nasal polyps away after surgery

NCT ID NCT07316959

Disease control Sponsor: Fatima Jinnah Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking a low dose of the antibiotic clarithromycin for three months after sinus surgery could prevent nasal polyps from coming back early. 100 adults who had surgery for nasal polyps were split into two groups: one received the antibiotic plus standard care, the other standard care alone. After 12 weeks, only 12% of the antibiotic group had polyp recurrence, compared to 32% in the control group, and they also reported better symptom scores.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
clarithromycin (a macrolide antibiotic)
What this could lead to
If confirmed, this could offer a simple, low-cost way to reduce the chance of nasal polyps coming back after surgery.
What could go wrong
This was a small, single-center study with only 100 participants. The results need to be repeated in larger, longer trials before becoming standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

100 people

The number who actually took part.

Started

Jan 2025

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria Male and female patients aged 15 to 75 years Clinical diagnosis of nasal polyps Underwent endoscopic sinus surgery Willing and able to provide informed consent Exclusion Criteria Current or recent use of antibiotics or macrolide therapy History of multiple facial fractures Presence of neurological disorders Presence of psychiatric or psychological disorders

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic rhinosinusitis with nasal polyps

Contacts and locations

Locations

  • Muhammad Shouzib Sultan

    Lahore, Punjab Province, 54780, Pakistan

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