CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

This study looks at whether people with chronic sinusitis and nasal polyps can safely take their biologic medication (like dupilumab or mepolizumab) less often without losing symptom control. About 135 adults who have been stable on the standard 4-week schedule will be followed t…

This study tests if adding dupilumab to standard nasal spray treatment helps people with chronic sinusitis and nasal polyps feel better and smell again. It focuses on minority groups often left out of research. Sixty adults will take the drug and report changes in symptoms and sm…

This study tests an injectable drug called SHR-1905 for people with chronic sinusitis and nasal polyps (growths in the nose). It aims to see if the drug can shrink polyps and reduce congestion better than a placebo. About 280 adults who have not responded well to standard nasal s…

This study tests whether transplanting healthy nasal bacteria into people with chronic sinusitis can reduce symptoms like congestion and discharge. About 50 adults with long-term sinusitis will receive either a real transplant or a placebo, and then switch groups. The goal is to …

This study looks at whether endoscopic sinus surgery can improve sleep problems in people with chronic rhinosinusitis and nasal polyps. About 30 adults who have not responded to medication will have their sleep measured before and 3 months after surgery. The goal is to see if rem…

This study tests an investigational drug called itepekimab in adults with chronic sinusitis and nasal polyps that are not well controlled by standard treatments. About 210 participants will receive either the drug or a placebo for up to 52 weeks, alongside their usual nasal stero…

This study tests a drug called tezepelumab in 180 adults with chronic sinusitis and nasal polyps who are eligible for surgery. The goal is to see if the drug can reduce nasal congestion and other sinus symptoms over 24 weeks. Participants receive the drug every 4 weeks and report…

This early-stage lab study uses nasal cells from people with chronic sinusitis and nasal polyps to see how the drug mepolizumab affects inflammation and cell barrier health. The study is small (8 participants) and takes place in a lab, not in patients directly. It aims to underst…

This study observes 200 Chinese patients with chronic sinusitis and nasal polyps after surgery to understand their symptoms, quality of life, and disease control over one year. Researchers will track how patients feel and whether their condition returns. The goal is to gather rea…