CARDIOMYOPATHIES

This study tests whether destroying small areas of heart muscle that cause dangerous rhythms (ventricular tachycardia ablation) during LVAD implant surgery can reduce the number of these rhythms after surgery. About 100 adults with advanced heart failure who are getting an LVAD w…

This early-stage study tests a gene therapy called AAVrh.10hFXN for heart disease caused by Friedreich's ataxia, a rare genetic disorder. The therapy delivers a working copy of the frataxin gene via a single IV infusion. The main goal is to check safety in 25 people aged 12 to 50…

This study tests a special pacing technique called high-intensity his bundle pacing in 34 adults with heart failure and a narrow QRS pattern on their ECG. Standard pacing doesn't help these patients, but this new approach may improve heart function and quality of life. Participan…

This study tests whether colchicine, a common anti-inflammatory drug, can help people with chronic heart muscle inflammation (inflammatory cardiomyopathy). About 80 adults with this condition will receive either colchicine or a placebo to see if it prevents worsening heart failur…

This study tests the Cardiohelp device, a heart-lung machine for children with severe heart failure, to see if it is safe and works well for up to 30 days. It also compares two blood thinners, heparin and bivalirudin, to find which causes fewer bleeding or clotting problems. Abou…

This study tests if a non-invasive radiation treatment (SBRT) can reduce dangerous heart rhythms as well as the standard catheter ablation procedure in 60 people with advanced heart disease. Participants will be randomly assigned to receive either radiation or catheter ablation. …

This study is testing whether an AI program called Willem can analyze ECG recordings as accurately as a human cardiologist. Over 5,000 high-risk heart patients will have their ECGs reviewed by both the AI and a doctor. The goal is to see if the AI can detect dangerous heart rhyth…

This phase 3 trial tests whether acoramidis can prevent or delay transthyretin amyloidosis (ATTR) in 587 adults who carry a faulty gene but have no symptoms yet. ATTR causes sticky plaques to build up in the heart and nerves, leading to heart failure and nerve damage. Acoramidis …

This study is looking for new genes and blood markers linked to arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can lead to heart failure and sudden cardiac arrest. Researchers will enroll 1,000 people, including patients with AVC or unexplained cardiac arrest…

This study aims to describe how a genetic heart condition called PKP2-ACM naturally progresses over time in people who receive standard care. Researchers will monitor heart rhythm, biomarkers, and quality of life in 36 participants aged 12 and older. The goal is to better underst…

This study follows 1,500 people with heart failure who already have an implantable defibrillator (ICD) to understand why some experience life-threatening heart rhythms and others do not. Researchers will analyze heart structure, electrical signals, genetics, and blood proteins to…

This study tests whether a wrist-worn sensor (PPG) can estimate how well the heart pumps blood, compared to standard ultrasound. About 500 adults getting an echocardiogram will wear the device. If successful, this could lead to simpler, cheaper heart monitoring.

This study involves 60 people with advanced heart failure who have a HeartMate 3 heart pump. The goal is to develop a way to monitor heart function using only data from the pump itself, without extra tests. Researchers will compare this new method with standard procedures like ul…

This study looks at heart tissue samples from 216 adults who already need a biopsy as part of their care. Researchers want to find unique molecular patterns in different heart conditions, including after a heart transplant. The goal is to improve how these diseases are diagnosed …

This study creates an online registry for 10,000 adults with cardiomyopathy or myocarditis (heart muscle diseases). Researchers will track health events like heart failure, arrhythmias, and death over time to better understand these conditions. Participants join from home and are…

This study is looking for genetic heart problems that might cause sudden unexpected death in people with epilepsy. Researchers will test the DNA of 600 adults with epilepsy or related conditions, plus their relatives, to find known heart-related gene mutations. The goal is to bet…