CARDIOMYOPATHIES

This study tests the Cardiohelp device, a heart-lung machine, in up to 50 children with severe heart failure to see if it is safe and effective for up to 30 days. It also compares two blood thinners, heparin and bivalirudin, to find which causes fewer bleeding or clotting problem…

This study tests if a precise form of radiation therapy (SBRT) can reduce dangerous heart rhythms better than the usual catheter ablation in 60 people with advanced heart disease. Participants will be randomly assigned to receive either radiation or ablation, and researchers will…

This study tests whether the experimental drug acoramidis can prevent or delay heart and nerve damage in people who carry a faulty gene for transthyretin amyloidosis (ATTR) but have no symptoms yet. About 582 adults aged 18 to 75 with a known disease-causing TTR gene variant will…

This study follows 36 people aged 12 and older who have a genetic heart condition called PKP2-ACM. Researchers will monitor heart rhythms, biomarkers, and quality of life over time to understand how the disease naturally progresses under standard care. No new treatments are given…

This study follows 1,500 people with heart failure who are getting a replacement for their implantable defibrillator (ICD). Researchers want to learn why some people have dangerous heart rhythms and how to better predict sudden cardiac death. Participants will provide medical dat…

This study is testing a cloud-based artificial intelligence program called Willem that reads electrocardiograms (ECGs) to detect heart rhythm problems. Researchers will compare the AI's readings to those of expert cardiologists. Over 5,000 high-risk heart patients will participat…

This study is looking for genetic heart problems in people with epilepsy that might raise their risk of sudden unexpected death. Researchers will test DNA from 600 adults and their relatives to find known heart-related gene changes. The goal is to better understand why some epile…