CARDIAC DISEASE

This study tests a device called Efferon LPS that filters harmful substances from the blood during and shortly after heart surgery. The goal is to see if it can lower the risk of multiple organ failure, a serious complication. About 60 adults having heart surgery with a heart-lun…

This study tests whether colchicine, an anti-inflammatory drug, can prevent organ damage caused by inflammation after heart surgery. About 768 adults aged 50-80 having planned heart surgery will receive colchicine or a placebo. Researchers will monitor for complications like new …

This study looks at 150 women having heart bypass surgery to see which second-best graft works better: a leg vein taken with a special 'no-touch' method or an arm artery. The goal is to find out which graft stays open longer and causes fewer complications. Results will help docto…

This study tests whether giving heparin (a blood thinner) during heart catheterization through the wrist can prevent the wrist artery from closing up afterward. About 1,600 adults having this procedure will be randomly assigned to receive no blood thinner, a low dose, or a high d…

This study tests whether two drugs, colchicine and ticagrelor, can reduce inflammation and lower the risk of another stroke or heart attack in people who have already had a stroke. About 2,800 high-risk participants will take these medications alongside standard care. The goal is…

This study looks at a new way to pace the heart called left bundle branch area pacing (LBBAP) for people with conditions like slow heartbeat, heart failure, or atrial fibrillation. About 200 adults will get a special pacemaker lead, and researchers will track safety issues like i…

This study compares two treatments for bleeding after heart surgery: FEIBA (a drug that helps blood clot) versus fresh frozen plasma (standard care). About 140 adults having non-emergency heart surgery will be enrolled. The goal is to see if FEIBA reduces the need for blood trans…

This study aims to create a computer program that can tell if a newborn's heart sounds are normal or abnormal using a digital stethoscope. Researchers will record heart sounds from 1,000 babies under 30 days old, some healthy and some with known heart disease, to train the progra…

This study tests whether a rectus sheath block, a type of nerve block, can reduce pain and the need for opioid painkillers after cardiac surgery. About 75 adults having heart surgery with chest tubes will be randomly assigned to get the block or not. Researchers will measure pain…

This study looks back at five years of medical records from older adults (60+) who had hip or other bone surgery after a fall or injury. Researchers want to see if a simple frailty score or a heart test before surgery better predicts who does well afterward. The goal is to improv…

This study compares AI-powered heart MRI scans to standard scans in 50 adults with heart disease. The goal is to see if the AI method improves patient satisfaction and reduces scan time. Participants are randomly assigned to one of the two scan types.

This study is a registry that will follow about 12,500 people with heart disease who receive Boston Scientific heart devices (like pacemakers or ablation tools). Its main goal is to track how safe and well the devices work over time, as required by European regulations. Participa…

This study looks at how medicines behave in the bodies of up to 2,000 critically ill children under 21 in the heart intensive care unit. Researchers collect leftover blood samples and medical data to better understand drug dosing and safety. No new drugs are given—only standard c…

This study looks at how the brain, nervous system, and blood vessels interact in 80 adults having heart surgery. Researchers will measure brain activity, heart rate control, and blood flow to see how these systems work together. The goal is to better understand why some people de…