BRCA1 MUTATION

This early-stage trial is testing a combination of two chemotherapy drugs (melphalan and BCNU) plus vitamins B12b and C, followed by an infusion of the patient's own stem cells. The goal is to see if this approach is safe for people with metastatic pancreatic or breast cancer, es…

This study is testing an experimental drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow their…

This study tests whether taking a targeted drug (olaparib) plus hormone therapy for 6 months before prostate removal surgery can eliminate or shrink tumors in men with high-risk prostate cancer. Participants must have specific gene changes (HRR alterations). The goal is to see if…

This study tests whether adding elacestrant to the standard drug olaparib can help people with a certain type of advanced breast cancer (HR-positive, HER2-negative) that has a BRCA gene mutation. About 176 participants will be randomly assigned to receive either the combination o…

This early-stage study tests whether combining two drugs, niraparib and irinotecan, is safe and effective for people with advanced solid tumors that have mutations in DNA repair genes like BRCA, ATM, or PALB2. The goal is to find the best dose with manageable side effects. About …

This early-phase study tests a combination of two oral drugs, olaparib and ASTX727, in adults with advanced solid tumors that have mutations in genes like BRCA1, BRCA2, PALB2, ATM, or CHEK2. The main goals are to find the safest dose and to check for side effects. About 18 partic…

This study is testing an experimental drug called ACE-86225106 in adults with advanced solid tumors that are difficult to treat or have stopped responding to standard therapies. The drug works by blocking a protein that helps cancer cells repair themselves, potentially slowing or…

This study aims to create a large collection of blood samples from 2,500 people with or at high risk for cancer. Researchers will use these samples to study liquid biopsies, which are blood tests that may help detect cancer, track treatment response, and spot recurrence. Particip…

This study looks at two new approaches to cancer genetic counseling. The first helps doctors reach out to family members who may have inherited a cancer-related gene change, making it easier for them to get tested. The second uses an online portal to keep patients and their docto…

This study tests whether an online program with a medical navigator and educational video helps more first-degree relatives of BRCA mutation carriers get genetic testing compared to standard care. About 820 participants will be split into two groups to see which approach works be…

This study aims to gather health information from 10,000 women in Italy who carry BRCA1 or BRCA2 gene mutations, which increase the risk of breast and ovarian cancers. By collecting data on where these mutations occur and how they affect health, researchers hope to improve preven…

This study tests a new educational guide to help women with BRCA mutations decide whether to take hormone replacement therapy after having their ovaries and fallopian tubes removed to lower cancer risk. About 50 premenopausal women scheduled for this surgery will receive either t…