BIPOLAR I DISORDER

This study tests a long-acting injection of cariprazine given once a month under the skin. It is for people with schizophrenia, bipolar I disorder, or major depressive disorder who are stable on other medications. The goal is to see if the injection is safe, tolerable, and effect…

This study aims to find the best weight-loss medication for people with bipolar disorder by matching drugs to specific obesity types (like 'hungry brain' or 'hungry gut'). About 100 adults aged 18-65 with bipolar or schizoaffective disorder and obesity will receive one of three F…

This study compares a new crystallized lithium capsule (AL001) to standard lithium carbonate in 20 adults with bipolar I disorder. Participants take each drug for 14 days and undergo MRIs and blood tests to see how the drugs behave in the brain and body. The goal is to find out i…

This study tests a new drug called icalcaprant for adults with bipolar I or II disorder who are currently depressed. About 195 participants will take either the drug or a placebo daily for 6 weeks. Researchers will measure changes in depression symptoms and check for side effects…

This study compares a new drug, OLZ/SAM, to the standard medication olanzapine in 220 teens aged 10-17 with schizophrenia or bipolar I disorder. The goal is to see if OLZ/SAM causes less weight gain over 12 weeks and up to a year. Participants must have a reliable family member o…

This study tests whether taking magnesium and vitamin B6 alongside usual treatment can reduce symptoms of depression, anxiety, and stress in people who recently started experiencing bipolar I disorder. About 40 adults aged 18 to 50 with a first episode in the last 10 years will r…

This study tests a new medication called azetukalner for people with bipolar I or II disorder who are currently in a depressive episode. Researchers want to see if it reduces depression symptoms better than a placebo over 6 weeks. The trial involves 400 adults aged 18 to 74 and i…

This study tests an experimental drug, NBI-1117568, to see if it can reduce manic symptoms in adults with bipolar I disorder who are hospitalized for a manic episode. About 150 participants will receive either the drug or a placebo for 21 days. The main goal is to measure changes…

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce symptoms like psychosis, depression, and mania in people recently diagnosed with bipolar I or schizoaffective disorder. Fifty adults aged 18-45 will follow the diet for 12 weeks alo…

This study tests whether limiting eating to a 10-hour window each day is a safe and practical addition to standard treatment for bipolar disorder. Forty adults with bipolar I or II who are currently experiencing depression will either receive nutritional counseling alone or combi…

This study tests an experimental drug called LB-102 to see if it can safely reduce depression in people with bipolar I disorder. About 320 adults will be randomly assigned to receive either the drug or a placebo for 6 weeks. The main goal is to measure changes in depression sympt…

This study tests whether cariprazine, a drug already approved for adults, can safely ease depressive episodes in children aged 10 to 17 with bipolar I disorder. About 380 participants will receive either the drug or a placebo for 6 weeks, with dose adjustments based on response. …

This study follows 80 youth aged 9-19 with bipolar disorder to learn what affects their mood over time. Researchers will track symptoms, inflammation, and family relationships. The goal is to improve diagnosis and treatment for young people with this condition.

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve how accurately adults in Hong Kong remember and report past mental health problems. Researchers will compare the standard interview method with the cale…