BIPOLAR I DISORDER
Clinical trials for BIPOLAR I DISORDER explained in plain language.
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Major study pits four bipolar depression drugs Head-to-Head
Disease control OngoingThis study compares four commonly prescribed medications for bipolar depression in over 2,700 adults. Participants receive one of three FDA-approved drugs or a combination therapy. The goal is to see which treatment leads to remission, meaning fewer depressive symptoms and better…
Matched conditions: BIPOLAR I DISORDER
Phase: PHASE4 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated May 26, 2026 03:26 UTC
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Teens with bipolar or schizophrenia sought for long-term drug safety check
Disease control ENROLLING_BY_INVITATIONThis study looks at the long-term safety of a drug called OLZ/SAM in teenagers with schizophrenia or bipolar I disorder. About 236 teens who finished a previous related study can join. The main goal is to track any side effects over time.
Matched conditions: BIPOLAR I DISORDER
Phase: PHASE3 • Sponsor: Alkermes, Inc. • Aim: Disease control
Last updated May 26, 2026 03:22 UTC
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New drug shows promise for Long-Term bipolar depression control
Disease control ENROLLING_BY_INVITATIONThis study tests the long-term safety and effectiveness of azetukalner in 400 adults with bipolar I or II depression who already completed a previous study on the same drug. Participants will take the medication openly (everyone knows they are getting it) for an extended period. …
Matched conditions: BIPOLAR I DISORDER
Phase: PHASE3 • Sponsor: Xenon Pharmaceuticals Inc. • Aim: Disease control
Last updated May 11, 2026 20:50 UTC
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Sweat away the blues: study tests exercise as bipolar depression treatment
Symptom relief TerminatedThis study looks at whether moderate-to-vigorous aerobic exercise can speed up recovery from bipolar depression and help prevent future depressive episodes. Fifty-four adults with bipolar disorder and current depression will be randomly assigned to either supervised aerobic exerc…
Matched conditions: BIPOLAR I DISORDER
Phase: NA • Sponsor: Region Stockholm • Aim: Symptom relief
Last updated May 22, 2026 13:49 UTC
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Brain scans reveal how gentle magnetic pulses affect bipolar depression in older adults
Knowledge-focused OngoingThis study looks at how low field magnetic stimulation changes brain activity in people aged 60 and older with bipolar depression. About 40 participants will have brain scans before and after real or fake treatment on two separate days. The goal is to understand the brain effects…
Matched conditions: BIPOLAR I DISORDER
Phase: NA • Sponsor: Mclean Hospital • Aim: Knowledge-focused
Last updated May 22, 2026 13:52 UTC