ANATOMIC STAGE III BREAST CANCER AJCC V8
Clinical trials for ANATOMIC STAGE III BREAST CANCER AJCC V8 explained in plain language.
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New vaccine aims to train immune system against aggressive breast cancer
⭐️ VACCINE ⭐️ OngoingThis study tests a DNA-based vaccine called STEMVAC in 33 people with early-stage triple negative breast cancer (stages IB to III). The vaccine targets proteins found on breast cancer stem cells and aims to train the immune system to recognize and attack these cells. The main goa…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: ⭐️ VACCINE ⭐️
Last updated May 22, 2026 14:03 UTC
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New drug combo shows promise for Hard-to-Treat breast cancer
Disease control OngoingThis study tests a new drug (TVB-2640) combined with standard treatments for people with HER2+ breast cancer that has spread and no longer responds to standard therapy. The goal is to see if the combination can shrink tumors or slow the disease. About 17 adults with advanced brea…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 26, 2026 09:06 UTC
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New drug combo aims to stop aggressive breast Cancer's return
Disease control OngoingThis phase 3 trial tests whether adding tucatinib to the standard drug T-DM1 can better prevent HER2-positive breast cancer from returning in high-risk patients. About 1,056 participants who still have cancer after initial treatment will receive either T-DM1 alone or T-DM1 plus t…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated May 26, 2026 09:02 UTC
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New combo attack on Hard-to-Treat cancers shows early promise
Disease control OngoingThis early-phase trial tests a combination of two drugs—trastuzumab deruxtecan (a targeted chemotherapy) and ceralasertib (which blocks a DNA repair enzyme)—in people with advanced solid tumors that have a HER2 mutation. The goal is to find the safest dose and see if the combo wo…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 08:59 UTC
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New combo therapy targets tough breast cancer in phase II trial
Disease control OngoingThis study tests whether a drug called olaparib (a PARP inhibitor) works better alone or combined with atezolizumab (an immunotherapy) for people with advanced non-HER2-positive breast cancer that has a BRCA mutation. About 81 participants with locally advanced or metastatic dise…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 08:59 UTC
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New combo therapy targets Hard-to-Treat cancers in early trial
Disease control OngoingThis early-phase study tests a new drug called BAY 1895344 combined with standard chemotherapy (cisplatin, with or without gemcitabine) in people with advanced solid tumors, especially bladder cancer. The main goals are to find the safest dose and understand side effects. About 7…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 08:58 UTC
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New drug combo shows promise in slowing advanced breast cancer
Disease control OngoingThis study tested whether adding the drug entinostat to standard hormone therapy (exemestane) helps people with advanced hormone receptor-positive breast cancer live longer without their cancer growing. About 600 adults with breast cancer that had spread or come back took part. T…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 08:35 UTC
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Could estrogen fight an aggressive breast cancer? new trial investigates
Disease control OngoingThis study tests if a form of estrogen called estradiol can help people with a specific type of triple negative breast cancer that has spread. The cancer must have a protein called ER beta, which may make it sensitive to estrogen. Researchers want to see if the treatment can shri…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 22, 2026 13:55 UTC
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New 'Twinkling' marker could make breast cancer surgery more precise
Disease control TerminatedThis early-stage study tests a new type of marker that shows up brightly on ultrasound, helping surgeons find and remove cancerous lymph nodes during breast cancer surgery. The study involves 15 adults with breast cancer that has spread to nearby lymph nodes. The goal is to see i…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 20, 2026 11:53 UTC
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New drug cocktail shows promise for Tough-to-Treat breast cancer
Disease control OngoingThis study tests two drugs, eribulin and copanlisib, together in people with metastatic triple-negative breast cancer that has spread or cannot be removed. The goal is to find the safest dose and see if the combination helps stop or slow tumor growth. About 24 adults with this ag…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 19, 2026 11:59 UTC
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New drug combo targets BRCA cancers in early trial
Disease control OngoingThis early-phase trial tests a combination of two drugs—niraparib (a PARP inhibitor) and dostarlimab (an immunotherapy)—in people with BRCA-mutated breast, pancreas, or ovarian cancers that have spread or cannot be surgically removed. The goal is to see if the combo can shrink tu…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: University of Washington • Aim: Disease control
Last updated May 18, 2026 12:13 UTC
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Triple-Drug attack on Hard-to-Treat cancers shows early promise
Disease control OngoingThis early-phase study tests the safety and best doses of three drugs—entinostat, nivolumab, and ipilimumab—given together to people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if this combination can help the immune system figh…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 15, 2026 11:55 UTC
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New combo therapy shows promise for HIV patients with advanced cancer
Disease control OngoingThis early-phase trial is testing the safety of combining two cancer drugs—nivolumab and cabozantinib—in people with HIV who have advanced solid tumors. The study includes 8 participants with various cancers that have spread. The goal is to see if the combination can shrink or st…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 11, 2026 20:38 UTC
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PET scans may guide breast cancer therapy before surgery
Diagnosis OngoingThis study tests whether a special PET/CT scan (FDG-PET/CT) can predict how well HER2-positive breast cancer responds to chemotherapy before surgery. About 235 adults with stage II-III breast cancer will get the scan early in treatment. The goal is to see if the scan can help doc…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Diagnosis
Last updated May 26, 2026 08:19 UTC
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Writing away the pain: new study for chinese breast cancer survivors
Symptom relief OngoingThis study tests whether a culturally tailored expressive writing program can improve quality of life for Chinese immigrant women who had breast cancer. About 256 women who finished treatment within the last 5 years will write about their experiences. Researchers will measure cha…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated May 26, 2026 09:07 UTC
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Can yoga and diet help breast cancer survivors feel better? new study says maybe.
Symptom relief OngoingThis study looks at whether two different health programs are practical and liked by breast cancer survivors. About 106 people who finished treatment for early-stage breast cancer will try either an Ayurveda program (with diet, yoga, and touch therapy) or a health education progr…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: University of California, San Francisco • Aim: Symptom relief
Last updated May 26, 2026 09:03 UTC
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New web tool aims to ease life for young breast cancer survivors
Symptom relief OngoingThis study tests a web-based portal called YES that helps young breast cancer survivors track symptoms and find resources. About 400 women aged 15-39 who had early-stage breast cancer will use the portal or get standard care. The goal is to see if the portal improves quality of l…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief
Last updated May 26, 2026 08:55 UTC
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Texts and calls boost breast cancer pill taking in major trial
Symptom relief OngoingThis study tests whether adding text message reminders and telephone counseling helps breast cancer patients take their daily hormone therapy pills more consistently. About 1,167 women with early-stage hormone receptor-positive breast cancer will be followed for up to two years. …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Symptom relief
Last updated May 22, 2026 14:04 UTC
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Walking through chemo: new study tests exercise for seniors with breast cancer
Symptom relief OngoingThis study looks at whether a simple exercise program—walking and arm exercises—is doable for women aged 65 and older while they receive chemotherapy for early-stage breast cancer. About 30 participants will be asked to exercise several times a week during their treatment. The go…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated May 22, 2026 13:53 UTC
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Can a digital kitchen program help breast cancer survivors eat better?
Symptom relief OngoingThis study tests a program called MIND that delivers nutrition and cooking lessons online to breast cancer survivors. The goal is to see if it helps improve diet quality and increase fruit and vegetable intake. About 49 people with stage I-III breast cancer will participate, and …
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Fred Hutchinson Cancer Center • Aim: Symptom relief
Last updated May 22, 2026 13:53 UTC
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Can a chatbot cure insomnia in breast cancer survivors?
Symptom relief OngoingThis study tests a text-message chatbot called Cecebot to see if it helps breast cancer survivors with insomnia sleep better. The chatbot combines sleep therapy and physical activity tips. About 60 women with stage I-III breast cancer and poor sleep will try it for 6 weeks. The g…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: University of Washington • Aim: Symptom relief
Last updated May 22, 2026 13:50 UTC
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Proton vs X-Ray: which radiation causes fewer side effects for breast cancer patients?
Symptom relief OngoingThis study compares two types of radiation therapy—standard x-ray and proton beam—for women with breast cancer who have had surgery. The goal is to see which method causes fewer serious side effects or unplanned surgeries over two years. About 146 women with stage I to III breast…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE3 • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated May 18, 2026 12:13 UTC
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New program aims to boost quality of life for seniors after breast cancer
Symptom relief OngoingThis study looks at whether a special geriatric care program can help older adults (65+) feel better after finishing treatment for early-stage breast cancer. The program includes a full check-up of physical and mental health, plus follow-up visits. Researchers hope this will redu…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated May 15, 2026 12:07 UTC
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New study aims to keep young breast cancer patients on lifesaving pills
Symptom relief OngoingThis study tests whether regularly checking in on symptoms, along with providing educational materials, helps young women (ages 18-44) with early-stage hormone-positive breast cancer continue taking their hormone therapy as prescribed. Many women stop these pills early due to sid…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: SWOG Cancer Research Network • Aim: Symptom relief
Last updated May 07, 2026 18:39 UTC
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Blood test may reveal hidden cancer after breast cancer surgery
Knowledge-focused TerminatedThis study looks at a blood test that finds tiny bits of tumor DNA in the blood of people with early-stage breast cancer. The goal is to see if this test can tell who still has cancer cells after treatment and might need more therapy. About 350 adults with stage I-III breast canc…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: City of Hope Medical Center • Aim: Knowledge-focused
Last updated May 26, 2026 09:07 UTC
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Cancer survivors share fertility hopes in landmark survey
Knowledge-focused OngoingThis study surveys women aged 18-45 who have had gynecological or breast cancer to learn how they think about having children after cancer. Researchers will use the results to help future patients make informed decisions about treatment and family planning. The study involves foc…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 26, 2026 09:06 UTC
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Genetic test may predict chemo nerve pain in black women
Knowledge-focused OngoingThis study looks at whether a genetic test can identify African American women with breast cancer who are more likely to develop nerve damage from taxane chemotherapy. Researchers compare two chemo drugs, docetaxel and paclitaxel, to see which causes fewer nerve problems. About 2…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Knowledge-focused
Last updated May 26, 2026 09:04 UTC
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New study tracks shoulder pain after breast cancer radiation
Knowledge-focused OngoingThis study looks at shoulder and arm problems in people with lymph-node positive breast cancer who receive radiation therapy. About 61 participants will be followed for one year after treatment to see how often shoulder issues occur with two different radiation techniques. The go…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated May 26, 2026 08:59 UTC
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Scientists build model to predict chemo nerve damage
Knowledge-focused OngoingThis study looks at over 1,300 cancer patients to find out who is more likely to develop nerve damage (tingling or numbness in hands and feet) from taxane chemotherapy. Researchers will track factors like age, gender, and pre-existing conditions to create a prediction tool. The g…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: SWOG Cancer Research Network • Aim: Knowledge-focused
Last updated May 26, 2026 08:56 UTC
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Massive biobank aims to unlock Cancer's secrets
Knowledge-focused OngoingThis study collects tissue and blood samples, along with medical information, from 1,600 people with various advanced cancers. The goal is to track how cancer changes over time and during treatment. Researchers hope this will help them understand why some cancers resist therapy a…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated May 22, 2026 13:54 UTC
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Gene test may guide breast cancer treatment choices
Knowledge-focused OngoingThis study looks at whether testing tumor genes can help predict if HER2-negative breast cancer will respond to standard treatments like chemotherapy or hormone therapy. About 1,100 people with early-stage breast cancer (stages I to III) will have their tumor samples analyzed. Th…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 20, 2026 11:53 UTC
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Cancer fear study pulled before starting
Knowledge-focused TerminatedThis study was designed to see if an online mental health program could help women with advanced gynecologic or breast cancer cope with the fear of their cancer coming back. It planned to compare the program to standard educational materials. However, the study was withdrawn befo…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: City of Hope Medical Center • Aim: Knowledge-focused
Last updated May 19, 2026 11:59 UTC
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New study aims to help older breast cancer patients make chemotherapy choices
Knowledge-focused OngoingThis study looks at how women aged 65 and older with early-stage breast cancer make decisions about chemotherapy. Researchers will interview patients and doctors to understand what information they need. The goal is to create a tool that helps patients and doctors weigh the risks…
Matched conditions: ANATOMIC STAGE III BREAST CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 18, 2026 12:00 UTC