ALZHEIMER DEMENTIA (AD)

This study is testing the drug lecanemab in 200 people with early-to-moderate Alzheimer's disease. Participants will receive either lecanemab or standard treatment for 24 months. Researchers will use brain scans, eye imaging, and memory tests to see if the drug slows the disease …

This study tests whether two HIV medications, emtricitabine and Descovy, are safe for people with mild cognitive impairment (MCI), a condition that can lead to Alzheimer's. Researchers think these drugs might slow memory decline by blocking a process linked to Alzheimer's. About …

This early-stage study tests a procedure called deep brain stimulation (DBS) for people with early Alzheimer's disease. It involves implanting a device that sends mild electrical pulses to a brain area involved in memory. The goal is to see if DBS can keep thinking and memory sta…

This study tests whether levetiracetam, a seizure medication, can prevent epileptic seizures in adults over 40 with Down syndrome who also have Alzheimer's disease. 120 participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop se…

This study tests a non-invasive treatment called transcranial pulse stimulation (TPS) for people with early Alzheimer's disease. TPS uses low-energy sound waves to stimulate the brain, aiming to improve thinking and memory. The study will involve 40 adults aged 60-90 and compare …

This study tests whether a 24-week online positive psychology program can improve memory, thinking, and well-being in older adults with very early signs of dementia. About 128 people with subjective cognitive decline or mild cognitive impairment will join. Half take the program (…

This study tests if combining a medication (methylphenidate) with a type of non-invasive brain stimulation can reduce apathy in people with Alzheimer's disease or mixed dementia. Apathy, or lack of motivation, is a common and troubling symptom. The study will involve 12 participa…

This early study is testing whether a natural supplement called fisetin is safe for older adults with mild Alzheimer's disease or mild cognitive impairment. Only 5 participants will take the supplement, and researchers will closely watch for any side effects. This is a very small…

This study looks at how blood flow and sugar use in the brain are different in people with Alzheimer's disease, especially those who also have type 2 diabetes. Researchers will use special PET scans to measure these changes without needles. The goal is to find early signs of dise…

This study uses a new ultra-high-resolution PET scanner to see tiny brain structures in much more detail than before. Researchers will scan 300 healthy volunteers and people with Alzheimer's, Parkinson's, ALS, or psychotic disorders to find early signs of disease. The goal is to …

This study aims to find genetic factors that increase the risk of developing dementia before age 70. Researchers will analyze DNA from 1,000 participants, including people with memory concerns or early-onset dementia and their family members. The goal is to better understand how …

This study looks at whether a combination of genetic tests, blood markers, and data from wearable devices can predict early memory problems in people aged 55 and older who carry the ApoE4 gene, which raises Alzheimer's risk. Researchers will follow 100 participants for two years …