Alzheimer dementia (AD)

This observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…

This early-stage trial will test whether higher-than-standard doses of memantine, a drug already approved for Alzheimer's, are safe and tolerable in 25 adolescents and young adults with Down syndrome. The study also looks for early signs that the drug might improve memory and thi…

This pilot trial tests whether an AI-powered virtual assistant, called VICA, can help family caregivers of people with Alzheimer's disease. The assistant provides education, symptom monitoring, and coaching through conversation. Sixty caregiver-patient pairs will be randomly assi…

This study tests whether listening to music at home can improve the quality of life and reduce burnout in people caring for a loved one with Alzheimer's. Ninety caregiver-patient pairs will be split into groups, with some listening to music or podcasts three times a week for 12 w…

This study will test whether advanced MRI scans and blood tests can predict how well Alzheimer's patients respond to antibody drugs like lecanemab and donanemab. Researchers aim to create personalized models that show when amyloid plaques have been cleared from the brain, potenti…

This study tests whether watching digital stories can help older adults in rural Vietnam learn about Alzheimer's and related dementias and encourage early diagnosis. Researchers will work with 100 older adults and their caregivers to see if this approach is feasible and improves …