ACUTE CORONARY SYNDROME

This study tests whether adding the antibiotic doxycycline to standard tuberculosis (TB) treatment can reduce lung damage and improve heart health. About 150 adults with active TB and lung cavities will receive either doxycycline or a placebo for 8 weeks. Researchers will measure…

This study looks at 2,600 adults with acute coronary syndrome who have had a stent placed and also have an H. pylori infection. They are given either a new drug (vonoprazan) plus amoxicillin or a standard acid reducer (pantoprazole) to see which better prevents stomach bleeding o…

This study is checking how well an FDA-approved device called the Guardian works in everyday use. The device is implanted in people at high risk for heart attacks and alerts them if a heart attack may be happening. Researchers will track 500 patients to see how accurate the alert…

This study compares two treatments—stenting (a less invasive procedure) and bypass surgery—for people with severe blockages in multiple heart arteries who are having a heart attack or unstable chest pain. The goal is to see if stenting is as good as surgery at preventing death, h…

This study compares a new AI-driven method (MPFFR) against the standard invasive FFR test to decide if and where to place stents in blocked heart arteries. About 2,100 adults with coronary artery disease will be randomly assigned to one of the two approaches. The goal is to see i…

This study looks at whether taking two blood thinners (aspirin plus ticagrelor) is better than aspirin alone for keeping bypass grafts open in people who had heart surgery after a heart attack. About 360 participants will be followed for 1 to 3 years, and their grafts will be che…

This study tests a new stomach acid-reducing drug (tegoprazan) against a standard one (rabeprazole) in about 3,320 heart patients who take blood thinners. The goal is to see if the new drug is as good at preventing serious stomach problems like bleeding and ulcers. Participants t…

This study tests whether a drug called colchicine, combined with a blood thinner, can safely replace aspirin after a heart stent procedure. About 490 participants will take colchicine and stop aspirin the day after their procedure. The goal is to see if this approach reduces hear…

This study tests whether combining three standard heart medications into one daily pill helps people who have had a heart attack stick to their treatment and avoid future heart problems. About 1,000 adults who recently had a heart attack and a stent placed will be randomly assign…

This study tests whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as two blood thinners (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 p…

This study tests a drug called dalcetrapib in 2,000 people who have a specific gene (AA genotype) and recently had a heart attack or related event. The goal is to see if the drug can prevent future heart attacks or strokes better than a placebo. Participants take the drug or a du…

This study tests whether starting the drug inclisiran early in the hospital can lower bad cholesterol more than a placebo in people with acute coronary syndrome (a serious heart condition). About 300 adults hospitalized for a heart attack or unstable angina will receive either in…

This study tests whether a risk score (OPT-CAD) can safely guide when to switch from two blood thinners to just one after a heart attack and stent placement. About 3,490 adults with acute coronary syndrome will be assigned to stop one blood thinner at either 1 or 3 months based o…

This study tests if a new, easier-to-use pressure microcatheter works as well as the standard pressure wire for guiding treatment of narrowed heart arteries. About 2500 adults with stable coronary artery disease or recent non-emergency heart attack will be randomly assigned to on…

This study tests a new type of heart stent made from magnesium that slowly dissolves over time, compared to a permanent metal stent. The goal is to see if the dissolvable stent is safe and works as well for people with blocked heart arteries. About 1,859 adults with coronary arte…

This study tests whether a radioactive tracer called Florbetaben, used with a PET scan, can detect inflamed plaques in the arteries of people who recently had a heart attack or stroke. About 30 participants will receive the tracer and undergo imaging to see if it highlights dange…

This study tests a new, noninvasive technique called magnetocardiography (MCG) to see if it can accurately identify heart attacks. Researchers will enroll about 3,800 healthy volunteers and people with chest pain. They will compare MCG results with standard tests like EKGs and bl…

This study tests if an online cognitive behavioral therapy (CBT) program can reduce heart-related anxiety in people who had a heart attack or unstable angina at least six months ago. About 176 adults with significant cardiac anxiety will either receive the online CBT or a digital…

This study tests a 12-week remote program that combines positive psychology and motivational interviewing, plus text messages, to help 280 heart attack survivors who are not very active. The goal is to see if this approach increases moderate-to-vigorous physical activity compared…

This study is testing a digital lifestyle platform designed to help patients with COPD, heart disease, fractures, or minor stroke maintain healthy habits after leaving inpatient rehabilitation. About 240 adults will use the platform, which offers personalized tips, educational co…

This study looks at 200 people having a heart attack to see if a special camera (OCT) inside the arteries correctly identifies the type of plaque that caused the attack. Researchers will compare the camera images with the actual plaque material removed during treatment. The goal …

This study is creating a registry of 100 women who have had a heart attack (acute coronary syndrome). Researchers will collect genetic, biochemical, and molecular information to better understand how heart attacks differ among women. The goal is to identify subtypes that could le…

This study is gathering information from 11,000 people who have had a heart attack or heart muscle injury. The goal is to better understand these conditions and improve future care. No new treatments or drugs are being tested—only data is being collected and analyzed.

This study is testing a new bedside device called CardiAQ MCG that measures magnetic fields from the heart to detect reduced blood flow (ischemia). Researchers will compare the device's readings with standard angiography results in 150 people scheduled for heart catheterization. …

This study looks at how two different stents (small mesh tubes placed in heart arteries) heal one month after being implanted. It involves 60 adults with acute coronary syndrome who also have a high risk of bleeding. Using a special camera called OCT, doctors will check how well …

This study looks at why heart disease affects women differently than men, especially after menopause. Researchers will measure inflammation and hormone levels in 6,000 women with chest pain. The goal is to understand how these factors influence heart attack risk and recovery, lea…