Tricuspid valve insufficiency

This study tests a new device called the VDyne System to replace the tricuspid valve in people with severe tricuspid regurgitation (a leaky heart valve). The goal is to see if the device is safe and can improve symptoms, exercise ability, and quality of life. About 30 adults with…

This early study tests a robotic catheter system to replace the tricuspid valve in 10 patients with severe leakage (regurgitation) who are too high-risk for open surgery. The robot aims to improve precision and safety while reducing radiation exposure for doctors. The main goal i…

This study tests a device called the Edwards PASCAL System, which is threaded through a blood vessel to repair a leaky tricuspid valve in the heart. It is for people with severe symptoms who are not good candidates for open-heart surgery. About 1,270 participants will be randomly…

This study tests a home-based cardiac rehabilitation program delivered through a custom app for people who have had a heart valve procedure. Participants who choose not to attend center-based rehab are randomly assigned to usual care, the app with self-guided content, or the app …

This study tests whether the Edwards EVOQUE system, a valve replacement delivered through a catheter, can safely and effectively treat tricuspid regurgitation, a condition where the tricuspid valve fails to close properly. Researchers will enroll 500 adults in Europe who are deem…

This study is checking how safe and well a device called TriClip works for people with a leaky heart valve (tricuspid regurgitation). The device is already approved for use, and this study will watch 1000 adults who get it to see how they do. The goal is to make sure the device w…

This study tests a new device called LuX-Valve Plus for people with a severely leaky heart valve (tricuspid regurgitation). About 680 adults will get either the new device or a standard one to see which is safer and works better. Participants will have one procedure and be follow…

This study tests a new device called the VDyne System, which is placed inside the heart through a tube in a blood vessel to replace a leaky tricuspid valve. The trial will include 730 people with severe symptoms who have not improved with medication. Researchers will compare the …

This study tests a new device called the VDyne System, which is placed through a tube in a blood vessel to replace the tricuspid valve in the heart. It is for people with severe tricuspid regurgitation, a condition where the valve does not close properly, causing blood to leak ba…

This study tests a new device, the Medtronic Intrepid™ TTVR System, to replace a leaky tricuspid heart valve without open-heart surgery. It is for people with severe symptoms despite medication. About 1,186 participants will be followed to see if the device reduces complications …

This early study is testing a new device called the TRiCares Topaz, which is threaded through a vein to replace the tricuspid valve in the heart. It is for adults with severe tricuspid valve leakage who are not good candidates for open-heart surgery. The study will check if the d…

This trial tests a new device, the Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System, designed to replace the tricuspid valve in people with severe, symptomatic tricuspid regurgitation. The procedure is done through a catheter, avoiding open-heart surgery. The study…

This early study tests a new device called the Laplace TTVR System, which is designed to replace the tricuspid valve without open-heart surgery. It involves 15 people aged 60-90 with severe tricuspid regurgitation that continues despite medication. The main goal is to see if the …

This trial tests a new device called the TruGamma system, which replaces the tricuspid valve without open surgery. It is for people aged 65 and older with severe tricuspid regurgitation who are not candidates for surgery. The study compares the device plus standard medication to …

This study tests a new device called DragonFly-T that clips a leaky tricuspid heart valve closed, avoiding open-heart surgery. About 236 people with severe symptoms who are too high-risk for surgery will be randomly assigned to get the clip or continue medical therapy. The goal i…

This early study is testing a new device called the DUO System, which is placed through a catheter to reduce leakage in the tricuspid valve. The study will include 15 people with severe tricuspid regurgitation who still have symptoms despite medical therapy. The main goal is to s…

This study looks at whether starting rhythm control early—using drugs or procedures like ablation—can improve outcomes for people with both atrial fibrillation and tricuspid regurgitation (a leaky heart valve). About 5,800 participants will be randomly assigned to early rhythm co…

This study follows 550 people who receive Abbott annuloplasty rings or bands during surgery to fix leaky mitral or tricuspid heart valves. Researchers will track survival, need for repeat surgery, and symptom improvement for five years. The goal is to confirm the devices work wel…

This study is testing a new device called the inQB8 MonarQ system, which replaces the tricuspid valve using a thin tube (catheter) instead of open-heart surgery. It includes 50 people with severe tricuspid regurgitation, a condition where the valve leaks. The goal is to see if th…

This study follows 100 adults with severe tricuspid regurgitation who receive the TricValve implant. Researchers will track survival, heart failure hospitalizations, kidney function, and quality of life for up to one year. The goal is to understand how well the device works and i…

This study tests a new device called the Cardiovalve system to treat severe tricuspid regurgitation, a condition where a heart valve leaks. About 150 people aged 18-84 who are too high-risk for open-heart surgery will receive the valve. The goal is to see if the valve safely redu…

This study tests a small implantable sensor that monitors pressure in the lung artery for patients with severe tricuspid regurgitation and heart failure. The sensor is placed before a minimally invasive valve repair, and pressure readings are tracked for a year. The goal is to se…

This study is testing a new device called the TRiCares Topaz system to replace a leaky heart valve (tricuspid valve) without open-heart surgery. It will enroll 80 adults with severe leakage who are at high risk for traditional surgery. The goal is to see if the device is safe and…

This study is checking how well the TriClip device works and how safe it is for people in Japan with a leaky tricuspid valve. The device is already approved for use, and this study will follow 250 patients to confirm its benefits in everyday medical practice. The main goal is to …

This study looks at whether a procedure to repair a leaky tricuspid heart valve can improve kidney function, reduce swelling, and boost physical activity in older adults. Researchers will follow 100 participants for changes in kidney health, walking ability, and daily function. T…

This trial tests a new device that clips together the leaflets of a leaky tricuspid valve, aiming to fix it without open-heart surgery. It will enroll 132 people with severe tricuspid regurgitation who are already on standard medications. The study compares the clip plus medicati…

This trial tests a device called 'Pivot Bridge' for people with a severe leaky heart valve (tricuspid regurgitation). The device is inserted through a leg vein and sits in the valve to help it close better. It is only used for about a week. The study involves 20 adults who have a…

This early study tests a new device called the Pivot Extend in 10 adults with severe tricuspid regurgitation (a leaky heart valve) who are too high-risk for surgery. The device is threaded through a vein in the leg to the heart, where it helps the valve flaps close tightly. The g…

This early study tests a new device called the Trisol System, which replaces the tricuspid valve using a tube inserted through blood vessels, avoiding open-heart surgery. It includes 30 adults with moderate or severe tricuspid regurgitation who have symptoms like shortness of bre…

This study is testing a new replacement valve for the tricuspid valve, which controls blood flow in the heart. The valve is made from natural materials and is designed to treat tricuspid valve disease in both adults and children. Researchers want to see if the valve can be safely…

This study tests whether a portable electronic stethoscope, combined with machine learning, can accurately detect valvular heart disease. About 125 people with and without the condition will use the device and also receive standard heart tests. Researchers will compare the device…

Tricuspid regurgitation happens when the heart's tricuspid valve leaks, letting blood flow backward. Open heart surgery to fix it carries high risks, and some people are not eligible for other catheter-based repairs. This study tests the Lux-Valve Plus, a replacement valve delive…

Researchers are studying how non-invasive tools can characterize tricuspid regurgitation, a heart valve condition linked to heart failure and liver problems. The trial enrolls 450 adults with moderate or worse tricuspid regurgitation and uses a lung fluid sensor and a liver stiff…

This global registry will follow 800 patients receiving a new, less-invasive tricuspid valve replacement (TTVR) for leaky heart valves. Researchers aim to track complications like pacemaker needs and how well the valve works over time. The study does not test a new drug but gathe…

This observational study follows 1000 adults with cardiac implantable electronic devices, such as pacemakers and defibrillators, to see how these devices affect tricuspid regurgitation, a condition where the heart's tricuspid valve leaks. Researchers will use 3D echocardiography …

This study will compare two newer pacemaker technologies—left bundle branch area pacing and leadless pacing—to see how they affect heart function and the tricuspid valve. Twenty adults with certain heart block conditions will receive both types temporarily during their routine pa…

This study follows 141 adults with atrial fibrillation and moderate-to-severe functional mitral or tricuspid valve regurgitation (leaky valves). Researchers will use echocardiograms, exercise tests, and blood work to identify patterns and predict how the disease progresses over o…

This study is observing 400 adults with moderate or severe tricuspid regurgitation, a condition where a heart valve does not close properly. Researchers will track participants over time to learn how the disease progresses and what factors affect survival. No new treatments are b…

This study is for people getting a minimally invasive procedure to fix leaky heart valves. Researchers will use MRI scans to see how the heart changes shape and works better after the procedure. The goal is to learn which patients benefit most and why, helping doctors improve fut…

This study uses 3D echocardiography to track changes in the tricuspid valve of 66 people with atrial fibrillation (AF) who do not yet have significant valve leakage. Researchers want to see if the valve's shape changes as AF becomes more persistent. The goal is to better understa…

This study tests whether artificial intelligence (AI) can help cardiologists read echocardiograms (heart ultrasounds) more quickly and consistently. Researchers will give AI analysis to doctors in real time as they review heart images from 50 participants with valve disease. The …

This study follows 200 adults who have had or will have a procedure to fix a leaky or narrowed valve in the right side of the heart. Researchers track survival, unplanned hospital stays, and heart function using blood tests and ultrasound. The goal is to learn which treatments wo…

This study aims to measure how often a heart valve leak (tricuspid regurgitation) develops or worsens after getting a pacemaker or defibrillator with a lead that crosses the valve. About 200 adults who need their first device will have heart ultrasounds before and after the proce…

This study is following 10,000 adults with heart valve disease to see how their condition changes over time. Researchers will use scans, blood tests, and health records to track progression and the effects of treatments like surgery or medication. The goal is to better predict ou…

This study uses artificial intelligence to analyze data from 21,000 patients who had heart valve procedures. The goal is to make AI tools that can predict surgery outcomes, like which device to use and risks of complications, with over 90% accuracy. This is a non-interventional s…

This study involves 70 adults with severe heart valve disease who are already scheduled for a routine heart catheterization. Researchers will use special catheters to measure how well the right side of the heart works with the lungs. The goal is to see if simpler, non-invasive te…