Toxic encephalopathy

This study looks at whether giving a protein called albumin through a vein can help improve thinking and memory in people with liver cirrhosis who have had episodes of confusion (hepatic encephalopathy). The trial will involve 30 participants who will receive both albumin and a p…

This study tests a new treatment called RTX001 for people with severe liver scarring (cirrhosis) that has led to complications. RTX001 uses the patient's own immune cells, modified in a lab to reduce inflammation and scarring. The trial will enroll 30 adults to check if the thera…

This study tests whether two drugs that calm the immune system—high-dose steroids or anti-thymocyte globulin—can help children with sudden, severe liver failure survive without needing a liver transplant. About 163 children aged 1 to 17 will be randomly assigned to receive one of…

This early-phase study tests a new type of CAR T-cell therapy for people with B-cell lymphoma that has come back or not responded to treatment. The cells are engineered to target and kill cancer cells, but also include a safety switch that can be activated to reduce severe side e…

This early-phase trial tests whether giving simvastatin (a cholesterol drug) and dexamethasone (a steroid) can safely prevent nerve-related side effects from axicabtagene ciloleucel (Axi-Cel) CAR-T therapy in adults with certain types of lymphoma. The study includes 37 participan…

This study tests whether transplanting healthy gut bacteria from donors can improve confusion in people with advanced liver disease. Thirty participants will receive either fecal transplant capsules or a placebo. The goal is to see if this approach can safely improve thinking and…

This study aimed to see if the antibiotic rifaximin could help people with liver cirrhosis who have a mild form of brain fog called covert hepatic encephalopathy, along with bacterial overgrowth in the gut. Researchers planned to give 40 patients rifaximin for eight weeks and tes…

This study tests whether the drug anakinra can prevent or reduce severe side effects like brain problems and cytokine release syndrome caused by CAR-T cell therapy. About 62 adults with certain B-cell blood cancers who are getting CAR-T treatment will receive anakinra. The goal i…

This Phase 3 study tests whether a special form of the antibiotic rifaximin can delay the first episode of overt hepatic encephalopathy (brain dysfunction) in people with liver cirrhosis who have controlled fluid buildup in the belly. About 466 participants will receive either ri…

This phase 3 trial compares radiation therapy alone versus radiation plus the chemotherapy drug temozolomide for people with symptomatic or progressive low-grade gliomas. The study enrolled 540 adults and aims to see if adding chemo improves how long patients live without their t…

The TREX trial tests whether a low-dose combination of sevoflurane, remifentanil, and dexmedetomidine leads to better long-term brain development than standard-dose sevoflurane in children under 2 who need anesthesia for at least 2 hours. Researchers will randomly assign 450 chil…

This study looks at whether adding lorazepam to haloperidol can better reduce delirium (sudden confusion and agitation) in people with advanced cancer who are in a palliative care unit. About 93 participants will receive either haloperidol alone or with lorazepam, and their level…

This study tracks 193 people who swallowed the herbicide diquat to see how the amount of poison in their blood relates to damage in organs like the brain. Researchers will also look at how well blood-filtering treatments work. The goal is to better predict who is at highest risk …

This study follows about 400 adults with liver cirrhosis admitted to internal medicine wards across Italy. Researchers will track how doctors manage hepatic encephalopathy—a brain complication of liver disease—during hospitalization and after discharge. The goal is to identify pr…

This study looks at how a person's genes and medical history might help predict nerve damage caused by chemotherapy. Researchers will follow 300 people with certain cancers who are scheduled for specific chemo drugs. The goal is to find patterns that could help prevent or reduce …

This study looks back at medical records of 624 adults with liver cirrhosis who had a procedure called TIPS to relieve pressure in the liver. The goal is to create a simple tool that helps doctors predict which patients are at high risk for a brain complication called hepatic enc…

This study follows 24 adults with liver cirrhosis who recently had a sudden worsening (decompensation) requiring hospital care. Researchers will track their health over time, including lab results and major events like death or liver transplant. The goal is to better understand t…