Blood levels may predict organ damage in diquat poisoning
NCT ID NCT06798142
First seen Jun 27, 2026 · Last updated Aug 19, 2026 · Updated 4 times
Summary
This study tracks 193 people who swallowed the herbicide diquat to see how the amount of poison in their blood relates to damage in organs like the brain. Researchers will also look at how well blood-filtering treatments work. The goal is to better predict who is at highest risk and improve emergency care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- extracorporeal treatment (blood filtering procedures like hemoperfusion and continuous dialysis)
- What this could lead to
- If successful, this could help doctors better predict organ damage in diquat poisoning and tailor treatments like blood filtering to improve survival.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly test a new therapy. Results may not apply to all poisoning cases, and the sample size is modest.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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193 people
The number who actually took part.
- Started
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Feb 2022
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with the history of acute diquat poisoning
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: 1. history of oral exposure to diquat solution reported by patient or proxy; 2. a specimen for the diquat plasma concentration collected immediately upon admission; 3. documentation that patients or, in case of unconsciousness of the patient, legal proxies were aware of and agreed to treatment plans. Exclusion criteria: 1. they had ingested other toxins in addition to diquat (qualitative toxicological screening tests); 2. diquat was not detected in specimens, or plasma concentration data were unavailable; 3. patients with an exposure time (time from exposure to emergency department presentation) longer than 48 hours; 4. data on organ damage were not unavailable; 5. combined with other central nervous system injuries other than toxic encephalopathy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Nanjing Drum Tower Hospital
Nanjing, Jiangsu, 210008, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.