Skin cancer

This study tests whether infliximab, a drug used for inflammatory conditions, can treat colitis (colon inflammation) caused by immune checkpoint inhibitors in people with stage III or IV skin cancer. About 42 participants will receive either infliximab or steroids, and researcher…

This study tests whether adding cetuximab to avelumab helps control advanced skin squamous cell carcinoma better than avelumab alone. About 60 adults with cancer that has spread will receive one of the two treatments. The goal is to see if the combination slows cancer growth and …

This phase II trial tests whether giving the immunotherapy drug cemiplimab before surgery can shrink high-risk skin cancers that have not spread far. The study enrolls 35 people with resectable squamous cell carcinoma. Participants receive cemiplimab intravenously, then undergo s…

This phase 2 trial is testing whether combining radiation therapy with the immunotherapy drug cemiplimab can effectively treat locally advanced skin cancer that cannot be surgically removed. The study involves 34 participants who will receive both treatments over about 12 months.…

This study is testing a device called DaRT that delivers alpha radiation directly into tumors. It is for people with skin cancer, mouth tumors, or superficial soft tissue sarcoma who have not responded to other treatments or cannot have standard therapy. The goal is to see if the…

This study tests whether adding focused radiation to a two-drug immunotherapy combination works better than the drugs alone for people with advanced Merkel cell carcinoma, a rare and aggressive skin cancer. About 50 adults with cancer that has spread or cannot be removed will rec…

This early-phase trial tests a new three-drug combination for people with advanced BRAF-mutated melanoma that cannot be removed by surgery. The drugs are XL888 (an HSP90 inhibitor), vemurafenib, and cobimetinib. The main goal is to find the safest dose of XL888 when given with th…

This early-phase study tested a new way of giving three drugs (encorafenib, binimetinib, and nivolumab) to people with advanced BRAF-mutant melanoma. Instead of taking the drugs every day, participants followed an on/off schedule to see if it could control the cancer while reduci…

This phase 3 trial tests whether a cream containing sirolimus (rapamycin) can prevent facial skin cancers in people who have received an organ transplant. 146 participants apply the cream or a placebo to their face every night for 6 months. The study counts new skin cancers durin…

This study aims to create a diagnostic test that can tell the difference between precancerous skin lesions (actinic keratoses) that will turn into skin cancer and those that will go away on their own. Researchers will study tissue samples from 140 patients with skin cancer and pr…

This study tests a special camera that uses light and sound to take 3D pictures of skin cancer. The goal is to see how deep and wide a tumor is before surgery. About 200 people with suspected skin cancer will take part. The images will be compared to standard lab results to see i…

This study compares an artificial intelligence (AI) model to dermatologists and other doctors in diagnosing skin lesions from photos. Researchers will show the same set of skin lesion images to the AI and to doctors, then compare their diagnoses to the actual diagnosis from a bio…

This early study tests a new radioactive tracer called 68Ga-FAPI-46, which targets a protein (FAP) found around many tumors. About 26 people with various cancers will get a PET/CT scan using this tracer to see where it goes in the body. The goal is to learn if this tracer can hel…

This study is testing a new, non-invasive camera that takes detailed images of skin lesions to see if it can detect skin cancer without needing a biopsy. Researchers are collecting images from nearly 1,900 people with skin lesions and comparing them to standard biopsy results. Th…

This trial tests whether giving young adults personalized risk information—such as a UV photo of their skin, a genetic test for melanoma risk, and a tailored action plan—can reduce sunburn and encourage sun protection. Over 500 college students who have had recent sunburns or tan…

This study planned to use online tools like ads and social media to encourage safer sun habits and reduce skin cancer risk. It was designed for men aged 18-65 who use Facebook and are interested in LGBT topics. However, the study was withdrawn before any participants were enrolle…

This study tests whether a combination of two creams—calcipotriene (a vitamin D cream) and 5-fluorouracil (a chemotherapy cream)—can prevent skin cancer in organ transplant recipients. These patients are at high risk for skin cancer, especially from precancerous spots called acti…

This study tests a personalized self-management program to help cancer survivors on immune checkpoint inhibitors better handle side effects and reduce anxiety or depression. About 400 adults with breast, colon, lung, skin, or rectal cancer who recently started immunotherapy will …

This early study tests whether short-term fasting (eating less than 200 calories per day for 3 days) before standard immunotherapy is safe and doable for people with advanced or metastatic skin cancer. Ten participants will receive their usual PD-1/PD-L1 inhibitor drugs along wit…

This study compares proton beam radiation to standard photon radiation (IMRT) for people with head and neck cancer. The goal is to see if proton therapy causes fewer side effects, like painful mouth sores, by exposing less healthy tissue to radiation. About 108 adults with certai…

This study investigates why some people are more susceptible to melanoma, a type of skin cancer. Researchers will compare the genes and sun exposure histories of people who have had multiple melanomas, those with a single melanoma, and similar people without melanoma. By analyzin…

This pilot study tests whether a community-based educational seminar can improve knowledge about melanoma and skin cancer. About 45 adults in Brooklyn will attend a session led by a community health worker and complete surveys over 12 months. The goal is to see if people learn mo…

This observational study collects extra tumor tissue from 416 people with various cancers (bladder, kidney, colorectal, head and neck, liver, lung, skin, endometrial) during routine biopsies. The goal is to develop and train a 'live tumor diagnostic platform' that can predict whe…

This study looks at whether teaching stem cell transplant survivors and their primary care doctors about skin cancer screening can lead to earlier detection. Participants receive educational materials and some doctors get a dermatoscope (a magnifying lens). The goal is to see if …

This study looks at blood samples from 20 adults with melanoma or other skin cancers to see if certain markers in the blood can predict how well treatment works or how long someone lives. Researchers will compare these markers to standard measures like tumor response and survival…

This study is looking at whether a blood test that detects circulating tumor DNA (ctDNA) can help predict if melanoma will come back or spread. Researchers are following 176 adult melanoma patients and comparing ctDNA levels with standard clinical and lab results. The goal is to …

This study asks 3000 people who had skin cancer surgery to fill out a one-time online survey about how they feel about their appearance, scars, and quality of life. The goal is to learn what matters most to patients after surgery. No new treatment or medication is being tested.

This study aimed to see if losing tiny, fine hairs (vellus hairs) on the eyelid could be a sign of skin cancer. Researchers planned to check patients before a biopsy and compare hair loss with the biopsy result. The study was withdrawn before it started, so no data was collected.