Rheumatic disorder

This study tested a program to help veterans with heart disease or rheumatic conditions take their medications as prescribed. Over 5,000 participants received reminders via text or phone calls, with extra support if needed. The goal was to improve medication adherence and reduce …

This trial tests whether giving children with autoimmune diseases (like inflammatory bowel disease or rheumatologic conditions) an extra booster dose of the flu vaccine improves their immune response compared to a single dose. These children take immunosuppressive medications tha…

This study will test whether a 6-week aerobic exercise program can improve quality of life, mood, and fatigue in women with rheumatoid arthritis. Sixty-four participants with low disease activity will either continue standard care or add five weekly exercise sessions. Researchers…

This study tested whether nurse-led consultations can help people with rheumatoid arthritis become more independent in managing their subcutaneous biotherapy. Many patients struggle to recognize warning signs and delay seeking help. The study enrolled 71 adults with rheumatoid ar…

This completed pilot study tested an 8-week online mindfulness course in 38 people with rheumatoid arthritis. The goal was to see if patients liked the program, what barriers they faced, and how it might affect symptoms. Half the group took the course while the other half receive…

This study tested whether a single injection of amniotic suspension allograft (ASA) can reduce pain and improve function in adults with knee osteoarthritis who haven't found relief from other treatments. About 594 participants received either ASA or a placebo, and their pain and …

This study tested two different exercise programs in 28 children and teens with rheumatic diseases like juvenile arthritis and familial Mediterranean fever. One program used external focus (thinking about the movement's effect), the other used internal focus (thinking about the b…

This Phase 2 trial tested a drug called LEVI-04 in 518 adults with knee osteoarthritis. The drug is designed to block pain signals. Researchers measured pain changes using a standard knee pain scale. The goal is to see if LEVI-04 can safely reduce pain and improve daily function.

This study tested whether an injection made from donated human amniotic tissue and cells (called ASA) can reduce pain and improve function in people with knee osteoarthritis. Over 500 adults with moderate to severe knee OA received either ASA or a placebo (salt water) injection. …

This study tested a cognitive exercise therapy approach called BETY in 52 children with juvenile idiopathic arthritis (JIA). The program combines exercises, pain management, and group activities to improve physical function and social well-being. Researchers compared it to a home…

This study tested two types of manual therapy (myofascial mobilization and joint mobilization) in 57 people with rheumatoid arthritis who also had jaw joint problems. Participants received therapy twice a week for six weeks, while a control group got no treatment. Both therapy gr…

This study tested whether a special suit called EXOPULSE Mollii can help adults with fibromyalgia feel less pain, fatigue, and depression. Twenty-eight participants wore either the active suit or a sham (fake) suit for two weeks, then had a washout period. After that, everyone co…

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This study tested a simple approach where doctors review pharmacy refill data during clinic visits and talk with patients about their medications. The goal was to see if this method is practical and acceptable for improving medication adherence in people with chronic rheumatic di…

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study is looking at how nutrition affects disease activity in people with rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will measure the nutritional status of 460 participants using several different tools and compare it to how act…

This completed study from France examined joint fluid from 20 people with arthritis to see if acid-sensing ion channels (ASICs) play a role in pain. Researchers wanted to find natural compounds that activate these channels during inflammation. The goal is to validate ASICs as tar…

This study followed 163 people with chronic inflammatory rheumatism (like rheumatoid arthritis) who had a recent COVID-19 infection. Researchers measured their antibody levels over two years to see how immunosuppressive drugs affect antibody persistence. The goal was to better un…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study tested a smartwatch and mobile app platform called Pedi@Ctivity to track physical activity in 362 adolescents, including those with chronic rheumatic disease. The goal was to collect big data and use AI to analyze activity patterns and create personalized exercise prog…

This study looked at over 13,000 people with chronic inflammatory rheumatism or autoimmune diseases who had or were suspected to have COVID-19. Researchers tracked how many developed severe COVID-19 requiring intensive care or leading to death. They also examined risk factors lik…

This study looked at 194 university students aged 18-30 to see how smartphone and digital game addiction relates to physical activity, sleep quality, stress, fatigue, and muscle or joint pain. Participants filled out questionnaires about their habits and health. The goal is to un…

This study looked at over 2,400 people with rheumatic diseases who take methotrexate. Researchers compared those who had standard lab monitoring to those who had fewer blood tests. The goal was to see if reduced monitoring is as safe in terms of preventing organ damage or death.

This completed study looked at anxiety about COVID-19 in 200 adults with rheumatic diseases who were already taking either biologic or conventional disease-modifying drugs. Researchers called participants and asked them to fill out a questionnaire about their coronavirus-related …

This study looked at whether video or phone visits (tele-rheumatology) work as well as in-person visits for people with rheumatic diseases like arthritis. Over 650 adults took part, and researchers measured how satisfied they were with each type of visit and which they preferred.…

This study followed 225 people who had ACL reconstruction surgery to see how their knees were doing 10 years later. Researchers looked at X-rays and pain scores to find out which factors increase the risk of developing osteoarthritis. The goal is to better understand long-term ou…

This study looked at how a special exercise approach called BETY affects people with rheumatic diseases (like arthritis) who have chronic pain. Researchers reviewed past records of 300 participants to see if BETY improved their physical function, mood, and quality of life compare…

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This study looked at how common joint pain and swelling are in 100 nursing home residents aged 65 and older, both with and without dementia. Researchers performed a physical exam and used simple pain questions or a special checklist for those with severe dementia. The goal was to…