Respiratory distress syndrome in premature infants

This trial tests whether a digital rehabilitation programme called I-IMPACT can be a practical alternative to traditional centre-based pulmonary rehabilitation for adults with interstitial lung disease (ILD). The study will compare the two approaches, focusing on feasibility—such…

This study compares a new type of breathing device (biphasic cuirass ventilator) to standard non-invasive ventilation in 50 high-risk patients who are about to have their breathing tube removed. The goal is to see if the new device can reduce the number of patients who need to be…

This study will test if a smart pill bottle cap, called FORTISKAP™, helps people with serious lung diseases like pulmonary fibrosis, sarcoidosis, and pulmonary hypertension take their oral medications more consistently. About 100 participants will either use the smart cap or rece…

This study tests whether giving the steroid betamethasone to extremely premature babies (born before 28 weeks) helps them come off breathing machines more easily and lowers their risk of chronic lung disease. About 100 babies will receive either standard NICU care plus betamethas…

This study tests whether a new breathing support called Pressure Targeted High Flow works as well as standard CPAP in premature infants with breathing problems. About 78 babies born before 33 weeks will try each method for 24 hours. Researchers will monitor breathing, oxygen need…

This study compares two types of high-frequency ventilators for premature babies born before 32 weeks who have breathing problems. The new mode, HFOV-VG, aims to deliver more stable breaths to reduce lung injury. Researchers will see if it lowers the chance of severe chronic lung…

This study tests whether giving a special lung medicine (surfactant mixed with budesonide) to extremely premature babies who are still on a breathing machine at 7-14 days old is safe and can help prevent a serious lung condition called bronchopulmonary dysplasia. About 24 babies …

This study tests whether a combination of three inhaled drugs (furosemide, heparin, and hypertonic saline) can reduce lung injury in adults with acute respiratory distress syndrome (ARDS) who are on mechanical ventilators. The trial will involve 344 participants and measure daily…

Researchers at Mayo Clinic are testing an investigational radioactive tracer called 68Ga-FAPI-46 to see how it distributes in the lungs of people with interstitial lung disease. About 10 participants with a clinical diagnosis of ILD and lung abnormalities on a recent CT scan rece…

Researchers are testing a noninvasive MRI technique that uses inhaled hyperpolarized xenon gas to measure lung function in adults with interstitial lung disease, pulmonary hypertension, and systemic sclerosis. The study includes about 51 participants, including healthy volunteers…

Researchers at Assiut University are testing whether lung ultrasound can diagnose pneumonia in newborns as reliably as the standard chest X-ray. The study will enroll 100 infants in the neonatal intensive care unit who have a clinical diagnosis of pneumonia within their first 28 …

This trial studies whether a slower inflation setting (long pressure rise time) on mechanical ventilators can improve oxygen levels in extremely preterm infants compared to the standard faster setting. About 68 babies born before 28 weeks will be randomly assigned to both setting…

This study tests whether a virtual reality (VR) program that guides slow, controlled breathing and arm exercises can help people with interstitial lung disease (ILD) manage symptoms like breathlessness and fatigue. Participants will either use a VR headset or follow printed instr…

This study looks at whether adding a type of stretching called proprioceptive neuromuscular facilitation (PNF) to standard breathing exercises helps patients get off a breathing machine faster. About 93 adults in the ICU who are stable and awake will be split into three groups: o…

This study tests a redesigned non-invasive ventilation mask that may help people with respiratory insufficiency breathe more easily. Sixty adults who are stable on NIV will wear their usual mask for one hour and then the new mask for one hour. Researchers will measure breathing r…

This study tests whether a supervised Clinical Pilates program can improve physical function, breathing, and quality of life in 58 adults with interstitial lung disease (ILD). Participants are randomly assigned to either Pilates sessions plus standard care or standard care alone.…

This study tests a procedure that freezes the nerves around broken ribs to see if it reduces pain and helps people breathe better. About 30 adults with at least two broken ribs and severe pain will either get the freezing treatment or standard pain medicine. Researchers will trac…

Interstitial lung diseases cause lung scarring and stiffness, making it hard to breathe. This study will test whether an 8-week pulmonary rehabilitation program—including walking, cycling, and strength exercises—can improve diaphragm function, exercise ability, and quality of lif…

This study aims to develop a new pain assessment scale, called EDEX, specifically for extremely premature infants born before 27 weeks. Current scales may not work well for these fragile babies, who show pain in subtle ways. Researchers will create the scale and then test it agai…

People with interstitial lung disease (ILD) can suddenly get much worse, but it is hard to tell if the cause is a lung flare-up or a blood clot in the lungs (pulmonary embolism). This observational study will follow 70 adults with ILD who come to the hospital with worsening breat…

This pilot study investigates how standard changes to mechanical ventilator settings—such as breath size, flow rate, and pressure—affect shortness of breath in awake patients on ventilators. Many ICU patients experience breathlessness despite sedation, which may contribute to PTS…

This study will track 427 adults with interstitial lung disease (ILD) who need a bronchoscopy as part of their care. Researchers want to see how often complications happen within 30 days after the procedure. The goal is to better understand the risks so doctors can make safer cho…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This study will observe 184 adults with acute respiratory distress syndrome (ARDS) who are on a breathing machine. Researchers want to see how different machine settings affect lung injury and survival. The goal is to find safer ways to use ventilators for these critically ill pa…

This study will use a procedure called bronchoalveolar lavage (BAL) to collect fluid from the lungs of 66 adults with suspected interstitial lung disease (ILD). The fluid will be analyzed to identify specific inflammatory cells, which may help doctors distinguish between differen…