Respiratory distress syndrome in premature infants

This trial tests whether adding gentle oscillations to standard nasal continuous positive airway pressure (NCPAP) improves breathing support for newborns with respiratory distress syndrome. Premature infants who need NCPAP will be randomly assigned to receive either oscillatory N…

This study tests whether giving surfactant (a natural substance that helps lungs stay open) through a small airway device placed above the vocal cords, along with standard breathing support (CPAP), is better than CPAP alone for late preterm and early term infants with respiratory…

This study is testing whether giving each patient on a ventilator a personalized oxygen target (based on their unique health data) leads to better outcomes than standard care. Researchers will compare death rates and time spent on the ventilator between the two groups. The trial …

This Phase 3 trial tests whether adding budesonide (an anti-inflammatory) to standard surfactant treatment helps extremely preterm babies avoid chronic lung disease or death. About 642 infants born before 29 weeks or weighing under 1000 grams will receive either the combo or surf…

This study tests whether using a portable oxygen concentrator (a lightweight, battery-powered device) during walking or exercise helps people with interstitial lung disease (ILD) or COPD feel less breathless and be more active in their daily lives. Twenty-four participants will t…

This pilot study tests whether home-based or video-supervised exercise programs are acceptable and helpful for people with chronic lung diseases like IPF, sarcoidosis, bronchiectasis, asthma, and other interstitial lung diseases. Fifty participants will be randomly assigned to on…

This study tests whether a radioactive tracer called 68Ga-FAPi-46 can light up areas of scarring (fibrosis) in the lungs of people with interstitial lung disease. Participants receive the tracer and undergo a PET/CT scan to see where it collects. The goal is to understand how the…

This study tests whether low-intensity aerobic exercise with blood flow restriction (BFR) is safe and effective for people with interstitial lung disease (ILD). BFR uses a cuff to partially block blood flow, which may help build muscle with less strain. Thirty participants will t…

This study looks for biological markers in blood and lung samples from people with idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases. The goal is to find markers that can predict how the disease will progress and to group patients into subtypes. Researchers…

This study looks at whether a simple bedside lung ultrasound can predict chronic lung disease in premature infants born before 32 weeks. Researchers will perform ultrasounds on 150 babies with breathing problems and track their outcomes. The goal is to see if early ultrasound sco…

This study observes how the diaphragm works in 100 adults with acute respiratory failure who need non-invasive breathing support or high-flow oxygen. Researchers use ultrasound to measure diaphragm movement and thickness at different support levels. The goal is to understand how …

This study looks at how things in the environment and at work might affect people with interstitial lung diseases (a group of lung conditions). Researchers will ask 1,000 adults with a new diagnosis about their exposures to things like pollution, chemicals, and dust. The goal is …

This study is observing brain oxygen levels in two groups of newborns at high risk of brain injury: full-term babies undergoing cooling treatment for oxygen deprivation, and extremely premature babies. Researchers use a non-invasive light sensor (near-infrared spectroscopy) to me…